3G60

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Multidrug resistance protein 1a	polymer	1284	141897.9	2	UniProt (Q5I1Y5) Pfam (PF00664) Pfam (PF00005) UniProt (by SIFTS) (P21447)	Mus musculus (mouse)	MCG1178
2	C, D (A, B)	(4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione	non-polymer		687.4	2	Chemie (0JZ)

Sequence modifications

A, B: 1 - 1276 (UniProt: Q5I1Y5)

PDB	External Database	Details
Tyr 1277	-	expression tag
Val 1278	-	expression tag
His 1279	-	expression tag
His 1280	-	expression tag
His 1281	-	expression tag
His 1282	-	expression tag
His 1283	-	expression tag
His 1284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	283795.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1374.8
All*	Total formula weight	285170.6

*Water molecules are not included.