3G60
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Multidrug resistance protein 1a | polymer | 1284 | 141897.9 | 2 | UniProt (Q5I1Y5) Pfam (PF00664) Pfam (PF00005) UniProt (by SIFTS) (P21447) In PDB | Mus musculus (mouse) | MCG1178 |
2 | A, B | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione | non-polymer | 687.4 | 2 | Chemie (0JZ) |
Sequence modifications
A, B: 1 - 1276 (UniProt: Q5I1Y5)
PDB | External Database | Details |
---|---|---|
Tyr 1277 | - | expression tag |
Val 1278 | - | expression tag |
His 1279 | - | expression tag |
His 1280 | - | expression tag |
His 1281 | - | expression tag |
His 1282 | - | expression tag |
His 1283 | - | expression tag |
His 1284 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 283795.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1374.8 | |
All* | Total formula weight | 285170.6 |