Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3G60

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007565biological_processfemale pregnancy
A0007595biological_processlactation
A0007623biological_processcircadian rhythm
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009914biological_processhormone transport
A0010033biological_processobsolete response to organic substance
A0010046biological_processresponse to mycotoxin
A0014070biological_processresponse to organic cyclic compound
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0031526cellular_componentbrush border membrane
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0033280biological_processresponse to vitamin D
A0033762biological_processresponse to glucagon
A0035633biological_processmaintenance of blood-brain barrier
A0036146biological_processcellular response to mycotoxin
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043215biological_processdaunorubicin transport
A0045177cellular_componentapical part of cell
A0045332biological_processphospholipid translocation
A0046581cellular_componentintercellular canaliculus
A0046686biological_processresponse to cadmium ion
A0046865biological_processterpenoid transport
A0050892biological_processintestinal absorption
A0055085biological_processtransmembrane transport
A0060856biological_processestablishment of blood-brain barrier
A0071217biological_processcellular response to external biotic stimulus
A0071222biological_processcellular response to lipopolysaccharide
A0071236biological_processcellular response to antibiotic
A0071312biological_processcellular response to alkaloid
A0071356biological_processcellular response to tumor necrosis factor
A0071392biological_processcellular response to estradiol stimulus
A0071407biological_processcellular response to organic cyclic compound
A0071475biological_processcellular hyperosmotic salinity response
A0071548biological_processresponse to dexamethasone
A0071549biological_processcellular response to dexamethasone stimulus
A0090554molecular_functionphosphatidylcholine floppase activity
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0097068biological_processresponse to thyroxine
A0097305biological_processresponse to alcohol
A0097327biological_processresponse to antineoplastic agent
A0099038molecular_functionceramide floppase activity
A0099040biological_processceramide translocation
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902065biological_processresponse to L-glutamate
A1902396biological_processprotein localization to bicellular tight junction
A1903416biological_processresponse to glycoside
A1904057biological_processnegative regulation of sensory perception of pain
A1904446biological_processpositive regulation of establishment of Sertoli cell barrier
A1904478biological_processregulation of intestinal absorption
A1905231biological_processcellular response to borneol
A1905232biological_processcellular response to L-glutamate
A1905233biological_processresponse to codeine
A1905235biological_processresponse to quercetin
A1905237biological_processresponse to cyclosporin A
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
A1990962biological_processxenobiotic transport across blood-brain barrier
A1990963biological_processestablishment of blood-retinal barrier
A2001025biological_processpositive regulation of response to drug
B0001666biological_processresponse to hypoxia
B0001890biological_processplacenta development
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0007565biological_processfemale pregnancy
B0007595biological_processlactation
B0007623biological_processcircadian rhythm
B0008559molecular_functionABC-type xenobiotic transporter activity
B0009410biological_processresponse to xenobiotic stimulus
B0009914biological_processhormone transport
B0010033biological_processobsolete response to organic substance
B0010046biological_processresponse to mycotoxin
B0014070biological_processresponse to organic cyclic compound
B0015562molecular_functionefflux transmembrane transporter activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016887molecular_functionATP hydrolysis activity
B0022857molecular_functiontransmembrane transporter activity
B0031526cellular_componentbrush border membrane
B0031667biological_processresponse to nutrient levels
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032570biological_processresponse to progesterone
B0033189biological_processresponse to vitamin A
B0033280biological_processresponse to vitamin D
B0033762biological_processresponse to glucagon
B0035633biological_processmaintenance of blood-brain barrier
B0036146biological_processcellular response to mycotoxin
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0043215biological_processdaunorubicin transport
B0045177cellular_componentapical part of cell
B0045332biological_processphospholipid translocation
B0046581cellular_componentintercellular canaliculus
B0046686biological_processresponse to cadmium ion
B0046865biological_processterpenoid transport
B0050892biological_processintestinal absorption
B0055085biological_processtransmembrane transport
B0060856biological_processestablishment of blood-brain barrier
B0071217biological_processcellular response to external biotic stimulus
B0071222biological_processcellular response to lipopolysaccharide
B0071236biological_processcellular response to antibiotic
B0071312biological_processcellular response to alkaloid
B0071356biological_processcellular response to tumor necrosis factor
B0071392biological_processcellular response to estradiol stimulus
B0071407biological_processcellular response to organic cyclic compound
B0071475biological_processcellular hyperosmotic salinity response
B0071548biological_processresponse to dexamethasone
B0071549biological_processcellular response to dexamethasone stimulus
B0090554molecular_functionphosphatidylcholine floppase activity
B0090555molecular_functionphosphatidylethanolamine flippase activity
B0097068biological_processresponse to thyroxine
B0097305biological_processresponse to alcohol
B0097327biological_processresponse to antineoplastic agent
B0099038molecular_functionceramide floppase activity
B0099040biological_processceramide translocation
B0140115biological_processexport across plasma membrane
B0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
B0140328molecular_functionfloppase activity
B0140359molecular_functionABC-type transporter activity
B1902065biological_processresponse to L-glutamate
B1902396biological_processprotein localization to bicellular tight junction
B1903416biological_processresponse to glycoside
B1904057biological_processnegative regulation of sensory perception of pain
B1904446biological_processpositive regulation of establishment of Sertoli cell barrier
B1904478biological_processregulation of intestinal absorption
B1905231biological_processcellular response to borneol
B1905232biological_processcellular response to L-glutamate
B1905233biological_processresponse to codeine
B1905235biological_processresponse to quercetin
B1905237biological_processresponse to cyclosporin A
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B1990962biological_processxenobiotic transport across blood-brain barrier
B1990963biological_processestablishment of blood-retinal barrier
B2001025biological_processpositive regulation of response to drug
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0JZ A 6001
ChainResidue
ATYR303
ATYR949
ASER975
AVAL978
AALA981
APHE332
ALEU335
AILE336
APHE339
AGLN721
APHE724
ASER725
APHE728

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0JZ B 6002
ChainResidue
BMET68
BPHE71
BPHE332
BPHE339
BGLN721
BPHE724
BPHE728
BTYR949
BLEU971
BPHE974
BSER975
BVAL978
BALA981

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
ChainResidueDetails
ALEU527-LEU541
ALEU1172-LEU1186

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1804
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-GLY43
BSER233-THR290
BGLU349-PHE707
BGLY774-ARG828
BGLU871-LYS930
BPRO992-SER1276
ALEU134-ILE182
ASER233-THR290
AGLU349-PHE707
AGLY774-ARG828
AGLU871-LYS930
APRO992-SER1276
BMET1-GLY43
BLEU134-ILE182

site_idSWS_FT_FI2
Number of Residues494
DetailsTRANSMEM: Helical
ChainResidueDetails
ATRP44-LEU66
ATRP851-VAL870
AALA931-PHE953
AVAL970-ALA991
BTRP44-LEU66
BTYR113-CYS133
BGLY183-PHE204
BLEU212-LEU232
BALA291-TYR312
BVAL327-ILE348
BVAL708-PHE728
ATYR113-CYS133
BLEU753-PHE773
BLEU829-TYR849
BTRP851-VAL870
BALA931-PHE953
BVAL970-ALA991
AGLY183-PHE204
ALEU212-LEU232
AALA291-TYR312
AVAL327-ILE348
AVAL708-PHE728
ALEU753-PHE773
ALEU829-TYR849

site_idSWS_FT_FI3
Number of Residues206
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET67-TYR112
BSER729-SER752
BGLY850
BARG954-ASN969
ATHR205-THR211
AGLY313-GLN326
ASER729-SER752
AGLY850
AARG954-ASN969
BMET67-TYR112
BTHR205-THR211
BGLY313-GLN326

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY423
AGLY1066
BGLY423
BGLY1066

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795
ChainResidueDetails
ASER656
BSER656

site_idSWS_FT_FI6
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN83
AASN87
AASN90
BASN83
BASN87
BASN90

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon