4KSB

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Summary for 4KSB

Related4KSC 4KSD 4LSG
DescriptorMultidrug resistance protein 1A (1 entity in total)
Functional Keywordstransporter, atp binding, membrane, membrane protein, transport protein
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Multi-pass membrane protein P21447
Total number of polymer chains1
Total molecular weight141877.88
Authors
Primary citation
Ward, A.B.,Szewczyk, P.,Grimard, V.,Lee, C.W.,Martinez, L.,Doshi, R.,Caya, A.,Villaluz, M.,Pardon, E.,Cregger, C.,Swartz, D.J.,Falson, P.G.,Urbatsch, I.L.,Govaerts, C.,Steyaert, J.,Chang, G.
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.
Proc.Natl.Acad.Sci.USA, 110:13386-13391, 2013
PubMed: 23901103 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1309275110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.8001 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.36117001.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ksb
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Molmil generated image of 4ksb
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Molmil generated image of 4ksb
rotated about y axis by 90°