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4KSB

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007565biological_processfemale pregnancy
A0007595biological_processlactation
A0007623biological_processcircadian rhythm
A0008559molecular_functionABC-type xenobiotic transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009914biological_processhormone transport
A0010033biological_processresponse to organic substance
A0010046biological_processresponse to mycotoxin
A0014070biological_processresponse to organic cyclic compound
A0015421molecular_functionABC-type oligopeptide transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0031526cellular_componentbrush border membrane
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0033280biological_processresponse to vitamin D
A0033762biological_processresponse to glucagon
A0035633biological_processmaintenance of blood-brain barrier
A0036146biological_processcellular response to mycotoxin
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0043215biological_processdaunorubicin transport
A0045177cellular_componentapical part of cell
A0045332biological_processphospholipid translocation
A0046581cellular_componentintercellular canaliculus
A0046686biological_processresponse to cadmium ion
A0046865biological_processterpenoid transport
A0050892biological_processintestinal absorption
A0055085biological_processtransmembrane transport
A0060856biological_processestablishment of blood-brain barrier
A0071217biological_processcellular response to external biotic stimulus
A0071222biological_processcellular response to lipopolysaccharide
A0071236biological_processcellular response to antibiotic
A0071312biological_processcellular response to alkaloid
A0071356biological_processcellular response to tumor necrosis factor
A0071392biological_processcellular response to estradiol stimulus
A0071407biological_processcellular response to organic cyclic compound
A0071475biological_processcellular hyperosmotic salinity response
A0071548biological_processresponse to dexamethasone
A0071549biological_processcellular response to dexamethasone stimulus
A0090554molecular_functionphosphatidylcholine floppase activity
A0090555molecular_functionphosphatidylethanolamine flippase activity
A0097068biological_processresponse to thyroxine
A0097305biological_processresponse to alcohol
A0097327biological_processresponse to antineoplastic agent
A0099038molecular_functionceramide floppase activity
A0099040biological_processceramide translocation
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902065biological_processresponse to L-glutamate
A1902396biological_processprotein localization to bicellular tight junction
A1903416biological_processresponse to glycoside
A1904057biological_processnegative regulation of sensory perception of pain
A1904446biological_processpositive regulation of establishment of Sertoli cell barrier
A1904478biological_processregulation of intestinal absorption
A1905231biological_processcellular response to borneol
A1905232biological_processcellular response to L-glutamate
A1905233biological_processresponse to codeine
A1905235biological_processresponse to quercetin
A1905237biological_processresponse to cyclosporin A
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
A1990962biological_processxenobiotic transport across blood-brain barrier
A1990963biological_processestablishment of blood-retinal barrier
A2001025biological_processpositive regulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL
ChainResidueDetails
ALEU527-LEU541
ALEU1172-LEU1186

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues902
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-GLY43
ALEU134-ILE182
ASER233-THR290
AGLU349-PHE707
AGLY774-ARG828
AGLU871-LYS930
APRO992-SER1276

site_idSWS_FT_FI2
Number of Residues247
DetailsTRANSMEM: Helical
ChainResidueDetails
ATRP44-LEU66
ATRP851-VAL870
AALA931-PHE953
AVAL970-ALA991
ATYR113-CYS133
AGLY183-PHE204
ALEU212-LEU232
AALA291-TYR312
AVAL327-ILE348
AVAL708-PHE728
ALEU753-PHE773
ALEU829-TYR849

site_idSWS_FT_FI3
Number of Residues103
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AMET67-TYR112
ATHR205-THR211
AGLY313-GLN326
ASER729-SER752
AGLY850
AARG954-ASN969

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY423
AGLY1066

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06795
ChainResidueDetails
ASER656

site_idSWS_FT_FI6
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN83
AASN87
AASN90

218853

PDB entries from 2024-04-24

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