4XWK

P-glycoprotein co-crystallized with BDE-100

Summary for 4XWK

DescriptorMultidrug resistance protein 1A, 2,4-dibromophenyl 2,4,6-tribromophenyl ether (2 entities in total)
Functional Keywordsmembrane protein, transporter, hydrolase
Biological sourceMus musculus (Mouse)
Cellular locationCell membrane; Multi-pass membrane protein P21447
Total number of polymer chains1
Total molecular weight142484.64
Authors
McGrath, A.P.,Rees, S.D.,Chang, G. (deposition date: 2015-01-28, release date: 2016-04-27, Last modification date: 2017-09-06)
Primary citation
Nicklisch, S.C.,Rees, S.D.,McGrath, A.P.,Gokirmak, T.,Bonito, L.T.,Vermeer, L.M.,Cregger, C.,Loewen, G.,Sandin, S.,Chang, G.,Hamdoun, A.
Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.
Sci Adv, 2:e1600001-e1600001, 2016
PubMed: 27152359 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1600001
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283500.7%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution