4XWK

P-glycoprotein co-crystallized with BDE-100

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0007507	biological_process	heart development
A	0007512	biological_process	adult heart development
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0008585	biological_process	female gonad development
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0009986	cellular_component	cell surface
A	0010467	biological_process	gene expression
A	0010498	biological_process	proteasomal protein catabolic process
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022008	biological_process	neurogenesis
A	0022857	molecular_function	transmembrane transporter activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0035640	biological_process	exploration behavior
A	0035932	biological_process	aldosterone secretion
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0045332	biological_process	phospholipid translocation
A	0046581	cellular_component	intercellular canaliculus
A	0046865	biological_process	terpenoid transport
A	0046943	molecular_function	carboxylic acid transmembrane transporter activity
A	0055007	biological_process	cardiac muscle cell differentiation
A	0055085	biological_process	transmembrane transport
A	0070633	biological_process	transepithelial transport
A	0072089	biological_process	stem cell proliferation
A	0090554	molecular_function	phosphatidylcholine floppase activity
A	0090555	molecular_function	phosphatidylethanolamine flippase activity
A	0097719	biological_process	neural tissue regeneration
A	0099038	molecular_function	ceramide floppase activity
A	0099040	biological_process	ceramide translocation
A	0140115	biological_process	export across plasma membrane
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140328	molecular_function	floppase activity
A	0140341	molecular_function	phosphatidylethanolamine floppase activity
A	0140359	molecular_function	ABC-type transporter activity
A	1905039	biological_process	carboxylic acid transmembrane transport
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
A	1990962	biological_process	xenobiotic transport across blood-brain barrier
A	2001225	biological_process	regulation of chloride transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue 4C8 A 1301

Chain	Residue
A	PHE331
A	PHE724
A	ILE727
A	PHE728
A	PHE755
A	PHE979

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
A	LEU527-LEU541
A	LEU1172-LEU1186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	247
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	103
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	218
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	303
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	236
Details	Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	289
Details	Domain: {"description":"ABC transmembrane type-1 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	238
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---