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8TUA
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BU of 8tua by Molmil
Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2023-08-15
Release date:2024-04-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Full-length P-Rex1 in complex with inositol 1,3,4,5-tetrakisphosphate (IP4)
Elife, 2024
8FW5
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BU of 8fw5 by Molmil
Chimeric HsGATOR1-SpGtr-SpLam complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K.
Deposit date:2023-01-20
Release date:2023-07-26
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing.
Structure, 31, 2023
8AE6
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BU of 8ae6 by Molmil
Cryo-EM structure of the SEA complex wing (SEACIT)
Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ...
Authors:Tafur, L, Loewith, R.
Deposit date:2022-07-12
Release date:2022-11-02
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structure of the SEA complex.
Nature, 611, 2022
8ADL
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BU of 8adl by Molmil
Cryo-EM structure of the SEA complex
Descriptor: Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ...
Authors:Tafur, L, Loewith, R.
Deposit date:2022-07-08
Release date:2022-11-02
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Cryo-EM structure of the SEA complex.
Nature, 611, 2022
7T3C
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BU of 7t3c by Molmil
GATOR1-RAG-RAGULATOR - Dual Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3B
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BU of 7t3b by Molmil
GATOR1-RAG-RAGULATOR - GAP Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3A
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BU of 7t3a by Molmil
GATOR1-RAG-RAGULATOR - Inhibitory Complex
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7SYF
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BU of 7syf by Molmil
Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera
Authors:Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M.
Deposit date:2021-11-24
Release date:2022-07-27
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
7SHF
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BU of 7shf by Molmil
Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex
Descriptor: (2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ...
Authors:Patil, D.N, Singh, S, Singh, A.K, Martemyanov, K.A.
Deposit date:2021-10-08
Release date:2021-12-01
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.
Science, 375, 2022
7RX9
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BU of 7rx9 by Molmil
Structure of autoinhibited P-Rex1
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION
Authors:Ellisdon, A.M, Chang, Y.
Deposit date:2021-08-22
Release date:2022-08-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat.Struct.Mol.Biol., 29, 2022
7PED
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BU of 7ped by Molmil
DEPTOR DEP domain tandem (DEPt)
Descriptor: DEP domain-containing mTOR-interacting protein
Authors:Waelchli, M, Jakob, R, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PEC
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BU of 7pec by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PEB
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BU of 7peb by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PEA
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BU of 7pea by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement
Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE9
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BU of 7pe9 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE8
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BU of 7pe8 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-08
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7PE7
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BU of 7pe7 by Molmil
cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement
Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Waelchli, M, Maier, T.
Deposit date:2021-08-09
Release date:2021-09-15
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Regulation of human mTOR complexes by DEPTOR.
Elife, 10, 2021
7OWG
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BU of 7owg by Molmil
human DEPTOR in a complex with mutant human mTORC1 A1459P
Descriptor: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ...
Authors:Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L.
Deposit date:2021-06-18
Release date:2021-09-08
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Elife, 10, 2021
7EWR
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BU of 7ewr by Molmil
Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio
Descriptor: Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7
Authors:Kim, Y, Jeong, E, Jeong, J, Cho, Y.
Deposit date:2021-05-26
Release date:2021-12-01
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5.
Nat Commun, 12, 2021
7EWP
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BU of 7ewp by Molmil
Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio
Descriptor: Guanine nucleotide-binding protein subunit beta-5, Probable G-protein coupled receptor 158, Regulator of G-protein signaling 7
Authors:Kim, Y, Jeong, E, Jeong, J, Cho, Y.
Deposit date:2021-05-25
Release date:2021-12-01
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the class C orphan GPCR GPR158 in complex with RGS7-G beta 5.
Nat Commun, 12, 2021
7DKL
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BU of 7dkl by Molmil
Crystal structure of the tandem DEP domains of DEPTOR
Descriptor: DEP domain-containing mTOR-interacting protein
Authors:Weng, Z.F, Shen, X.X, Liu, Y.F.
Deposit date:2020-11-24
Release date:2021-12-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains.
J.Mol.Biol., 433, 2021
6VSK
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BU of 6vsk by Molmil
Crystal structure of the P-Rex1 DEP1 domain
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Tesmer, J, Ravala, S.K.
Deposit date:2020-02-11
Release date:2020-07-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.
J.Biol.Chem., 295, 2020
6PCV
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BU of 6pcv by Molmil
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
Authors:Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
Deposit date:2019-06-18
Release date:2019-10-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
6N9G
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BU of 6n9g by Molmil
Crystal Structure of RGS7-Gbeta5 dimer
Descriptor: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7
Authors:Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A.
Deposit date:2018-12-03
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.129 Å)
Cite:Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex.
Elife, 7, 2018
6H7E
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BU of 6h7e by Molmil
GEF regulatory domain
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ...
Authors:Ferrandez, Y, Cherfils, J, Peurois, F.
Deposit date:2018-07-31
Release date:2020-02-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023

 

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PDB entries from 2024-09-18

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