6H7E

GEF regulatory domain

Summary for 6H7E

• Entry DOI: 10.2210/pdb6h7e/pdb
• Descriptor: cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: gef, camp, regulatory, membrane binding domain, epac, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 61423.74

Authors

Ferrandez, Y.,Cherfils, J.,Peurois, F. (deposition date: 2018-07-31, release date: 2020-02-19, Last modification date: 2023-12-20)

• Primary citation: Sartre, C.,Peurois, F.,Ley, M.,Kryszke, M.H.,Zhang, W.,Courilleau, D.,Fischmeister, R.,Ambroise, Y.,Zeghouf, M.,Cianferani, S.,Ferrandez, Y.,Cherfils, J.; Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.; Nat Commun, 14:4157-4157, 2023; PubMed: 37438343; DOI: 10.1038/s41467-023-39894-4

Experimental method

X-RAY DIFFRACTION (2.3 Å)