6VSK

Crystal structure of the P-Rex1 DEP1 domain

Summary for 6VSK

Entry DOI	10.2210/pdb6vsk/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (2 entities in total)
Functional Keywords	dep domain, p-rex1, metastasis, domain-swapped, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	10969.66
Authors	Tesmer, J.,Ravala, S.K. (deposition date: 2020-02-11, release date: 2020-07-22, Last modification date: 2023-10-11)
Primary citation	Ravala, S.K.,Hopkins, J.B.,Plescia, C.B.,Allgood, S.R.,Kane, M.A.,Cash, J.N.,Stahelin, R.V.,Tesmer, J.J.G. The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding. J.Biol.Chem., 295:12635-12647, 2020 Cited by PubMed: 32661198 DOI: 10.1074/jbc.RA120.014534 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.12 Å)

Structure validation