Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3ACX
DownloadVisualize
BU of 3acx by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673
Descriptor: Dehydrosqualene synthase, N-(1-methylethyl)-3-[(3-prop-2-en-1-ylbiphenyl-4-yl)oxy]propan-1-amine
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3VJD
DownloadVisualize
BU of 3vjd by Molmil
Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
Descriptor: Dehydrosqualene synthase, L(+)-TARTARIC ACID
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3VJ9
DownloadVisualize
BU of 3vj9 by Molmil
Crystal structure of the human squalene synthase
Descriptor: CALCIUM ION, NICKEL (II) ION, Squalene synthase
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3VJ8
DownloadVisualize
BU of 3vj8 by Molmil
Crystal structure of the human squalene synthase
Descriptor: Squalene synthase
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
2ZCO
DownloadVisualize
BU of 2zco by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus
Descriptor: Dehydrosqualene synthase
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
8IS9
DownloadVisualize
BU of 8is9 by Molmil
CrtMLIKE with one FsPP molecule
Descriptor: CrtM, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE
Authors:Park, J.Y.
Deposit date:2023-03-20
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:CrtMLIKE with one FsPP molecule
To Be Published
8ISA
DownloadVisualize
BU of 8isa by Molmil
CrtMLIKE with one GsPP molecule
Descriptor: CrtM, GERANYL S-THIOLODIPHOSPHATE
Authors:Park, J.Y.
Deposit date:2023-03-20
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:CrtMLIKE with one GsPP molecule
To Be Published
8IS7
DownloadVisualize
BU of 8is7 by Molmil
CrtMLIKE with two FsPP molecules.
Descriptor: CrtM, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE
Authors:Park, J.Y.
Deposit date:2023-03-20
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:CrtMLIKE with two FsPP molecules.
To Be Published
3ACW
DownloadVisualize
BU of 3acw by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-651
Descriptor: (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol, Dehydrosqualene synthase
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
7VWT
DownloadVisualize
BU of 7vwt by Molmil
Carbazole Prenyl Transferase CqsB4
Descriptor: 2-methyl-1-[(2R)-2-oxidanylpropyl]-9H-carbazole-3,4-dione, CqsB4, DI(HYDROXYETHYL)ETHER, ...
Authors:Suemune, H, Nagata, R, Kuzuyama, T, Nagano, S.
Deposit date:2021-11-11
Release date:2022-03-23
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes.
Angew.Chem.Int.Ed.Engl., 61, 2022
3WEG
DownloadVisualize
BU of 3weg by Molmil
Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion
Descriptor: MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J.
Deposit date:2013-07-07
Release date:2014-02-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
3VJA
DownloadVisualize
BU of 3vja by Molmil
Crystal structure of the human squalene synthase
Descriptor: NICKEL (II) ION, Squalene synthase
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
2ZY1
DownloadVisualize
BU of 2zy1 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830
Descriptor: Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2009-01-10
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
J.Med.Chem., 52, 2009
3WEI
DownloadVisualize
BU of 3wei by Molmil
Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate
Descriptor: MANGANESE (II) ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J.
Deposit date:2013-07-07
Release date:2014-02-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
3V66
DownloadVisualize
BU of 3v66 by Molmil
HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}-4-piperidinyl)acetic acid
Descriptor: (1-{[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}piperidin-4-yl)acetic acid, PHOSPHATE ION, Squalene synthase
Authors:Suzuki, M, Ohtsuka, M, Ohki, H, Haginoya, N, Itoh, M, Sugita, K, Usui, H, Ichikawa, M, Higashihashi, N.
Deposit date:2011-12-18
Release date:2012-12-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of novel tricyclic compounds as squalene synthase inhibitors
Bioorg.Med.Chem., 20, 2012
3ACY
DownloadVisualize
BU of 3acy by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-702
Descriptor: (1R)-4-[3-(2-benzylphenoxy)phenyl]-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-13
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase
Proc.Natl.Acad.Sci.USA, 107, 2010
3WEK
DownloadVisualize
BU of 3wek by Molmil
Crystal structure of the human squalene synthase F288L mutant in complex with presqualene pyrophosphate
Descriptor: MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J.
Deposit date:2013-07-07
Release date:2014-02-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
3WEH
DownloadVisualize
BU of 3weh by Molmil
Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate
Descriptor: MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J.
Deposit date:2013-07-07
Release date:2014-02-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
3ADZ
DownloadVisualize
BU of 3adz by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with intermediate PSPP
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2010-01-31
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
3VJC
DownloadVisualize
BU of 3vjc by Molmil
Crystal structure of the human squalene synthase in complex with zaragozic acid A
Descriptor: MAGNESIUM ION, PHOSPHATE ION, Squalene synthase, ...
Authors:Liu, C.I, Jeng, W.Y, Chang, W.J, Ko, T.P, Wang, A.H.J.
Deposit date:2011-10-14
Release date:2012-04-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
3WE9
DownloadVisualize
BU of 3we9 by Molmil
The crystal structure of YisP from Bacillus subtilis subsp. subtilis strain 168
Descriptor: Putative phytoene/squalene synthase YisP, TRIETHYLENE GLYCOL
Authors:Hu, Y, Huang, C.H, Chan, H.C, Ko, T.P, Feng, X, Oldfield, E, Guo, R.T.
Deposit date:2013-07-02
Release date:2014-07-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of Bacillus subtilis YisP in complex with a PEG fragment
To be Published
2ZCR
DownloadVisualize
BU of 2zcr by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-698
Descriptor: Dehydrosqualene synthase, MAGNESIUM ION, tripotassium (1R)-4-(4'-butylbiphenyl-4-yl)-1-phosphonatobutane-1-sulfonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E.
Deposit date:2007-11-11
Release date:2008-03-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
5IYS
DownloadVisualize
BU of 5iys by Molmil
Crystal structure of a dehydrosqualene synthase in complex with ligand
Descriptor: MAGNESIUM ION, Phytoene synthase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ...
Authors:Liu, G.Z, Liu, W.D, Chen, C.C, Guo, R.T.
Deposit date:2016-03-24
Release date:2017-03-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of a dehydrosqualene synthase in complex with ligand
to be published
4F6X
DownloadVisualize
BU of 4f6x by Molmil
Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1112
Descriptor: 1-[3-(hexyloxy)benzyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid, D(-)-TARTARIC ACID, Dehydrosqualene synthase, ...
Authors:Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E.
Deposit date:2012-05-15
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
ACS Med Chem Lett, 3, 2012
3TFP
DownloadVisualize
BU of 3tfp by Molmil
Crystal Structure of Dehydrosqualene Synthase (CrtM) from S. aureus Complexed with BPH-1162
Descriptor: 2-({2-chloro-6-[(2,4-dichlorophenyl)sulfanyl]benzyl}carbamoyl)benzoic acid, Dehydrosqualene synthase, MAGNESIUM ION
Authors:Lin, F.-Y, Liu, Y.-L, Zhang, Y, Oldfield, E.
Deposit date:2011-08-16
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
Chemmedchem, 7, 2012

 

123>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon