3VJA
Crystal structure of the human squalene synthase
Summary for 3VJA
| Entry DOI | 10.2210/pdb3vja/pdb |
| Related | 3VJ8 3VJ9 3VJB 3VJC 3VJD 3VJE |
| Descriptor | Squalene synthase, NICKEL (II) ION (3 entities in total) |
| Functional Keywords | farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268 |
| Total number of polymer chains | 2 |
| Total formula weight | 79015.32 |
| Authors | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Wang, A.H.J. (deposition date: 2011-10-14, release date: 2012-04-11, Last modification date: 2023-11-08) |
| Primary citation | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Ko, T.P.,Wang, A.H.J. Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287:18750-18757, 2012 Cited by PubMed: 22474324DOI: 10.1074/jbc.M112.351254 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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