3WEG
Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion
Summary for 3WEG
Entry DOI | 10.2210/pdb3weg/pdb |
Related | 3VJ8 3VJ9 3VJA 3VJB 3VJC 3VJD 3WEF 3WEH 3WEI 3WEJ 3WEK |
Descriptor | Squalene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40318.67 |
Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.J. (deposition date: 2013-07-07, release date: 2014-02-12, Last modification date: 2023-11-08) |
Primary citation | Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Shih, M.F.,Ko, T.P.,Wang, A.H.J. Structural insights into the catalytic mechanism of human squalene synthase. Acta Crystallogr.,Sect.D, 70:231-241, 2014 Cited by PubMed: 24531458DOI: 10.1107/S1399004713026230 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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