3WEG
Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Squalene synthase | polymer | 343 | 39449.0 | 1 | UniProt (P37268) Pfam (PF00494) | Homo sapiens (human) | SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase |
| 2 | B, C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E, F (A) | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | non-polymer | 398.4 | 2 | Chemie (FPS) | |||
| 4 | G (A) | water | water | 18.0 | 283 | Chemie (HOH) |
Sequence modifications
A: 31 - 370 (UniProt: P37268)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ser 29 | - | expression tag |
| His 30 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39449.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 869.7 | |
| All* | Total formula weight | 40318.7 |
