4F6X

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1112

Summary for 4F6X

Entry DOI	10.2210/pdb4f6x/pdb
Descriptor	Dehydrosqualene synthase, 1-[3-(hexyloxy)benzyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	dehydrosqualene synthase, virulence factor, bph-1112, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35284.81
Authors	Lin, F.-Y.,Zhang, Y.,Liu, Y.-L.,Oldfield, E. (deposition date: 2012-05-15, release date: 2012-06-20, Last modification date: 2023-09-13)
Primary citation	Zhang, Y.,Lin, F.-Y.,Li, K.,Zhu, W.,Liu, Y.L.,Cao, R.,Pang, R.,Lee, E.,Axelson, J.,Hensler, M.,Wang, K.,Molohon, K.J.,Wang, Y.,Mitchell, D.A.,Nizet, V.,Oldfield, E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3:402-406, 2012 Cited by PubMed: 22662288 DOI: 10.1021/ml300038t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation