3TFP

Crystal Structure of Dehydrosqualene Synthase (CrtM) from S. aureus Complexed with BPH-1162

Summary for 3TFP

Entry DOI	10.2210/pdb3tfp/pdb
Descriptor	Dehydrosqualene synthase, MAGNESIUM ION, 2-({2-chloro-6-[(2,4-dichlorophenyl)sulfanyl]benzyl}carbamoyl)benzoic acid, ... (4 entities in total)
Functional Keywords	head-to-head prenyl synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35302.87
Authors	Lin, F.-Y.,Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2011-08-16, release date: 2012-04-04, Last modification date: 2023-09-13)
Primary citation	Lin, F.Y.,Zhang, Y.,Hensler, M.,Liu, Y.L.,Chow, O.A.,Zhu, W.,Wang, K.,Pang, R.,Thienphrapa, W.,Nizet, V.,Oldfield, E. Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics. Chemmedchem, 7:561-564, 2012 Cited by PubMed: 22290830 DOI: 10.1002/cmdc.201100589 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation