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9IJE
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BU of 9ije by Molmil
Epinephrine-activated human beta3 adrenergic receptor
Descriptor: Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.34 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJD
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BU of 9ijd by Molmil
Carazolol-activated human beta3 adrenergic receptor
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ...
Authors:Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X.
Deposit date:2024-06-22
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker.
Chempluschem, 2024
9IJ9
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BU of 9ij9 by Molmil
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Gi complex
Descriptor: 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yuan, Q, Duan, J, Tao, L, Xu, E.H.
Deposit date:2024-06-21
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Cell Res., 2024
9IIX
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BU of 9iix by Molmil
A Cryo-EM structure of Bitter taste receptor TAS2R14 with Ggust
Descriptor: 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yuan, Q, Duan, J, Tao, L, Xu, E.H.
Deposit date:2024-06-21
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist.
Cell Res., 2024
9GAW
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BU of 9gaw by Molmil
High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
Deposit date:2024-07-29
Release date:2024-08-14
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
To Be Published
9FMD
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BU of 9fmd by Molmil
Integrative model of the human post-catalytic spliceosome (P-complex)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Rothe, P, Plaschka, C, Vorlaender, M.K.
Deposit date:2024-06-05
Release date:2024-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism for the initiation of spliceosome disassembly.
Nature, 2024
9F45
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BU of 9f45 by Molmil
cryo-EM structure of human LST2 bound to human mTOR complex 1
Descriptor: INOSITOL HEXAKISPHOSPHATE, Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR, ...
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F44
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BU of 9f44 by Molmil
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1
Descriptor: INOSITOL HEXAKISPHOSPHATE, Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR, ...
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F43
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BU of 9f43 by Molmil
cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR
Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F42
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BU of 9f42 by Molmil
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTOR
Descriptor: Lateral signaling target protein 2 homolog, Regulatory-associated protein of mTOR
Authors:Craigie, L.M, Maier, T.
Deposit date:2024-04-26
Release date:2024-08-14
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR.
Proc.Natl.Acad.Sci.USA, 121, 2024
9F1D
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BU of 9f1d by Molmil
Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9F1C
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BU of 9f1c by Molmil
Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9F1B
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BU of 9f1b by Molmil
Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9EYX
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BU of 9eyx by Molmil
Human PRMT5 in complex with AZ compound 28
Descriptor: (3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYW
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BU of 9eyw by Molmil
Human PRMT5 in complex with AZ compound 21
Descriptor: (3~{S})-2-[(5-azanyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-6-fluoranyl-1'-[(4-fluorophenyl)methyl]spiro[isoindole-3,3'-pyrrolidine]-1,2'-dione, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYV
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BU of 9eyv by Molmil
Human PRMT5 in complex with AZ compound 12
Descriptor: (1~{S})-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-2-(1~{H}-pyrrolo[3,2-b]pyridin-2-ylmethyl)-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9EYU
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BU of 9eyu by Molmil
Human PRMT5 in complex with AZ compound 1
Descriptor: (1~{S})-2-[(2-carbamimidamido-1,3-thiazol-5-yl)methyl]-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-1~{H}-isoindole-1-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein WDR77, ...
Authors:Debreczeni, J.
Deposit date:2024-04-09
Release date:2024-08-14
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
J.Med.Chem., 67, 2024
9ERX
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BU of 9erx by Molmil
Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor
Descriptor: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, Antibody ScFv16 Fab fragment, Cannabinoid receptor 1, ...
Authors:Thorsen, T.S, Kulkarni, Y, Boggild, A, Drace, T, Nissen, P, Gajhede, M, Boesen, T, Kastrup, J.S, Gloriam, D.
Deposit date:2024-03-25
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of Delta 9 -THC analog activity at the Cannabinoid 1 receptor.
Res Sq, 2024
9C8U
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BU of 9c8u by Molmil
Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min
Descriptor: Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Abe, K.M, Li, G, He, Q, Grant, T, Lim, C.
Deposit date:2024-06-13
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min
To Be Published
9C82
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BU of 9c82 by Molmil
Structure of human ULK1C:PI3KC3-C1 supercomplex
Descriptor: Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ...
Authors:Chen, M, Hurley, J.H.
Deposit date:2024-06-11
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (6.84 Å)
Cite:Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
bioRxiv, 2023
9BLN
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BU of 9bln by Molmil
The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex
Descriptor: 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ...
Authors:Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C.
Deposit date:2024-04-30
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
9BKK
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BU of 9bkk by Molmil
Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
9BKJ
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BU of 9bkj by Molmil
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
Descriptor: AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Last modified:2024-08-14
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
9BKD
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BU of 9bkd by Molmil
The structure of human Pdcd4 bound to the 40S small ribosomal subunit
Descriptor: 18S rRNA, 40S ribosomal protein S12, 40S ribosomal protein S13, ...
Authors:Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Albacete-Albacete, L, Ramakrishnan, V, S.Fraser, C.
Deposit date:2024-04-27
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
9BDP
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BU of 9bdp by Molmil
80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Loveland, A.B, Korostelev, A.A.
Deposit date:2024-04-12
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural mechanism of angiogenin activation by the ribosome.
Nature, 630, 2024

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PDB entries from 2024-09-18

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