9F45
cryo-EM structure of human LST2 bound to human mTOR complex 1
Summary for 9F45
Entry DOI | 10.2210/pdb9f45/pdb |
EMDB information | 50184 |
Descriptor | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR, ... (5 entities in total) |
Functional Keywords | mtor, mtorc1, lst2, zfyve28, egfr, tos, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 1150394.45 |
Authors | Craigie, L.M.,Maier, T. (deposition date: 2024-04-26, release date: 2024-08-14, Last modification date: 2024-08-28) |
Primary citation | Battaglioni, S.,Craigie, L.M.,Filippini, S.,Maier, T.,Hall, M.N. mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR. Proc.Natl.Acad.Sci.USA, 121:e2405959121-e2405959121, 2024 Cited by PubMed: 39141345DOI: 10.1073/pnas.2405959121 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.74 Å) |
Structure validation
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