9F45
cryo-EM structure of human LST2 bound to human mTOR complex 1
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL |
| Chain | Residue | Details |
| C | MET100-LEU114 |
| site_id | PS00915 |
| Number of Residues | 15 |
| Details | PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ |
| Chain | Residue | Details |
| A | LEU2186-GLN2200 |
| site_id | PS00916 |
| Number of Residues | 21 |
| Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN |
| Chain | Residue | Details |
| A | SER2323-ASN2343 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | ZN_FING: FYVE-type => ECO:0000255|PROSITE-ProRule:PRU00091 |
| Chain | Residue | Details |
| G | ASP817-PRO879 | |
| A | MET2345 | |
| A | ILE2356 | |
| B | SER2165 | |
| B | GLN2167 | |
| B | LEU2185 | |
| B | GLU2190 | |
| B | TYR2225 | |
| B | GLY2238 | |
| B | TRP2239 | |
| B | VAL2240 | |
| H | ASP817-PRO879 | |
| B | THR2245 | |
| B | MET2345 | |
| B | ILE2356 | |
| E | SER836 | |
| E | SER982 | |
| F | SER44 | |
| F | SER122 | |
| F | SER836 | |
| F | SER982 | |
| A | THR2245 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00091 |
| Chain | Residue | Details |
| G | CYS823 | |
| H | CYS826 | |
| H | CYS839 | |
| H | CYS842 | |
| H | CYS847 | |
| H | CYS850 | |
| H | CYS869 | |
| H | CYS872 | |
| G | CYS826 | |
| G | CYS839 | |
| G | CYS842 | |
| G | CYS847 | |
| G | CYS850 | |
| G | CYS869 | |
| G | CYS872 | |
| H | CYS823 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | SER334 | |
| H | SER334 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | THR516 | |
| H | THR516 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAP2K => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | SER586 | |
| H | SER586 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MAP2K => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | THR870 | |
| H | THR870 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | LYS87 | |
| F | SER738 | |
| H | LYS87 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131 |
| Chain | Residue | Details |
| E | SER791 | |
| F | SER791 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | SER792 | |
| F | SER792 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431 |
| Chain | Residue | Details |
| E | SER855 | |
| F | SER855 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER859 | |
| F | SER859 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER863 | |
| F | SER863 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | THR865 | |
| F | THR865 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER877 | |
| F | SER877 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715 |
| Chain | Residue | Details |
| E | LYS1097 | |
| F | LYS1097 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | THR700 | |
| F | THR700 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303 |
| Chain | Residue | Details |
| E | LYS932 | |
| E | LYS948 | |
| F | LYS932 | |
| F | LYS948 |
