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9F45

cryo-EM structure of human LST2 bound to human mTOR complex 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000822molecular_functioninositol hexakisphosphate binding
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0002181biological_processcytoplasmic translation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006446biological_processregulation of translational initiation
A0006511biological_processubiquitin-dependent protein catabolic process
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009615biological_processresponse to virus
A0009791biological_processpost-embryonic development
A0009891biological_processpositive regulation of biosynthetic process
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010508biological_processpositive regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0019216biological_processregulation of lipid metabolic process
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0038203biological_processTORC2 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045597biological_processpositive regulation of cell differentiation
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045824biological_processnegative regulation of innate immune response
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045947biological_processnegative regulation of translational initiation
A0045948biological_processpositive regulation of translational initiation
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050821biological_processprotein stabilization
A0050882biological_processvoluntary musculoskeletal movement
A0051219molecular_functionphosphoprotein binding
A0051240biological_processpositive regulation of multicellular organismal process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0097700biological_processvascular endothelial cell response to laminar fluid shear stress
A0106310molecular_functionprotein serine kinase activity
A0140367biological_processantibacterial innate immune response
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1902554cellular_componentserine/threonine protein kinase complex
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1903940biological_processnegative regulation of TORC2 signaling
A1904059biological_processregulation of locomotor rhythm
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905671biological_processregulation of lysosome organization
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
A2000767biological_processpositive regulation of cytoplasmic translation
A2000785biological_processregulation of autophagosome assembly
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000822molecular_functioninositol hexakisphosphate binding
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0002181biological_processcytoplasmic translation
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006446biological_processregulation of translational initiation
B0006511biological_processubiquitin-dependent protein catabolic process
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007040biological_processlysosome organization
B0007281biological_processgerm cell development
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009615biological_processresponse to virus
B0009791biological_processpost-embryonic development
B0009891biological_processpositive regulation of biosynthetic process
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010508biological_processpositive regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016605cellular_componentPML body
B0016740molecular_functiontransferase activity
B0019216biological_processregulation of lipid metabolic process
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035264biological_processmulticellular organism growth
B0038202biological_processTORC1 signaling
B0038203biological_processTORC2 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045335cellular_componentphagocytic vesicle
B0045597biological_processpositive regulation of cell differentiation
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045824biological_processnegative regulation of innate immune response
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045947biological_processnegative regulation of translational initiation
B0045948biological_processpositive regulation of translational initiation
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050821biological_processprotein stabilization
B0050882biological_processvoluntary musculoskeletal movement
B0051219molecular_functionphosphoprotein binding
B0051240biological_processpositive regulation of multicellular organismal process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0062027biological_processpositive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0097700biological_processvascular endothelial cell response to laminar fluid shear stress
B0106310molecular_functionprotein serine kinase activity
B0140367biological_processantibacterial innate immune response
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1902554cellular_componentserine/threonine protein kinase complex
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1903940biological_processnegative regulation of TORC2 signaling
B1904059biological_processregulation of locomotor rhythm
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905671biological_processregulation of lysosome organization
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990253biological_processcellular response to leucine starvation
B2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
B2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
B2000767biological_processpositive regulation of cytoplasmic translation
B2000785biological_processregulation of autophagosome assembly
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006974biological_processDNA damage response
C0007010biological_processcytoskeleton organization
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0030307biological_processpositive regulation of cell growth
C0030674molecular_functionprotein-macromolecule adaptor activity
C0030838biological_processpositive regulation of actin filament polymerization
C0031669biological_processcellular response to nutrient levels
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0032008biological_processpositive regulation of TOR signaling
C0032956biological_processregulation of actin cytoskeleton organization
C0038202biological_processTORC1 signaling
C0038203biological_processTORC2 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045821biological_processpositive regulation of glycolytic process
C0046889biological_processpositive regulation of lipid biosynthetic process
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0071456biological_processcellular response to hypoxia
C0071470biological_processcellular response to osmotic stress
C1902554cellular_componentserine/threonine protein kinase complex
C1905857biological_processpositive regulation of pentose-phosphate shunt
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006974biological_processDNA damage response
D0007010biological_processcytoskeleton organization
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0030307biological_processpositive regulation of cell growth
D0030674molecular_functionprotein-macromolecule adaptor activity
D0030838biological_processpositive regulation of actin filament polymerization
D0031669biological_processcellular response to nutrient levels
D0031929biological_processTOR signaling
D0031931cellular_componentTORC1 complex
D0031932cellular_componentTORC2 complex
D0032008biological_processpositive regulation of TOR signaling
D0032956biological_processregulation of actin cytoskeleton organization
D0038202biological_processTORC1 signaling
D0038203biological_processTORC2 signaling
D0043066biological_processnegative regulation of apoptotic process
D0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045821biological_processpositive regulation of glycolytic process
D0046889biological_processpositive regulation of lipid biosynthetic process
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0071456biological_processcellular response to hypoxia
D0071470biological_processcellular response to osmotic stress
D1902554cellular_componentserine/threonine protein kinase complex
D1905857biological_processpositive regulation of pentose-phosphate shunt
E0000045biological_processautophagosome assembly
E0001558biological_processregulation of cell growth
E0001938biological_processpositive regulation of endothelial cell proliferation
E0002181biological_processcytoplasmic translation
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006974biological_processDNA damage response
E0008361biological_processregulation of cell size
E0009267biological_processcellular response to starvation
E0009410biological_processresponse to xenobiotic stimulus
E0010494cellular_componentcytoplasmic stress granule
E0010506biological_processregulation of autophagy
E0010507biological_processnegative regulation of autophagy
E0010646biological_processregulation of cell communication
E0016020cellular_componentmembrane
E0019901molecular_functionprotein kinase binding
E0023051biological_processregulation of signaling
E0030291molecular_functionprotein serine/threonine kinase inhibitor activity
E0030295molecular_functionprotein kinase activator activity
E0030307biological_processpositive regulation of cell growth
E0030425cellular_componentdendrite
E0030674molecular_functionprotein-macromolecule adaptor activity
E0031267molecular_functionsmall GTPase binding
E0031669biological_processcellular response to nutrient levels
E0031929biological_processTOR signaling
E0031931cellular_componentTORC1 complex
E0032008biological_processpositive regulation of TOR signaling
E0035176biological_processsocial behavior
E0038202biological_processTORC1 signaling
E0043025cellular_componentneuronal cell body
E0044877molecular_functionprotein-containing complex binding
E0045672biological_processpositive regulation of osteoclast differentiation
E0045821biological_processpositive regulation of glycolytic process
E0045945biological_processpositive regulation of transcription by RNA polymerase III
E0045947biological_processnegative regulation of translational initiation
E0045948biological_processpositive regulation of translational initiation
E0046889biological_processpositive regulation of lipid biosynthetic process
E0061462biological_processprotein localization to lysosome
E0065008biological_processregulation of biological quality
E0071230biological_processcellular response to amino acid stimulus
E0071233biological_processcellular response to L-leucine
E0071333biological_processcellular response to glucose stimulus
E0071456biological_processcellular response to hypoxia
E0071470biological_processcellular response to osmotic stress
E0071889molecular_function14-3-3 protein binding
E0140767molecular_functionenzyme-substrate adaptor activity
E1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
E1901331biological_processpositive regulation of odontoblast differentiation
E1902554cellular_componentserine/threonine protein kinase complex
E1904263biological_processpositive regulation of TORC1 signaling
E1905857biological_processpositive regulation of pentose-phosphate shunt
F0000045biological_processautophagosome assembly
F0001558biological_processregulation of cell growth
F0001938biological_processpositive regulation of endothelial cell proliferation
F0002181biological_processcytoplasmic translation
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0005829cellular_componentcytosol
F0006974biological_processDNA damage response
F0008361biological_processregulation of cell size
F0009267biological_processcellular response to starvation
F0009410biological_processresponse to xenobiotic stimulus
F0010494cellular_componentcytoplasmic stress granule
F0010506biological_processregulation of autophagy
F0010507biological_processnegative regulation of autophagy
F0010646biological_processregulation of cell communication
F0016020cellular_componentmembrane
F0019901molecular_functionprotein kinase binding
F0023051biological_processregulation of signaling
F0030291molecular_functionprotein serine/threonine kinase inhibitor activity
F0030295molecular_functionprotein kinase activator activity
F0030307biological_processpositive regulation of cell growth
F0030425cellular_componentdendrite
F0030674molecular_functionprotein-macromolecule adaptor activity
F0031267molecular_functionsmall GTPase binding
F0031669biological_processcellular response to nutrient levels
F0031929biological_processTOR signaling
F0031931cellular_componentTORC1 complex
F0032008biological_processpositive regulation of TOR signaling
F0035176biological_processsocial behavior
F0038202biological_processTORC1 signaling
F0043025cellular_componentneuronal cell body
F0044877molecular_functionprotein-containing complex binding
F0045672biological_processpositive regulation of osteoclast differentiation
F0045821biological_processpositive regulation of glycolytic process
F0045945biological_processpositive regulation of transcription by RNA polymerase III
F0045947biological_processnegative regulation of translational initiation
F0045948biological_processpositive regulation of translational initiation
F0046889biological_processpositive regulation of lipid biosynthetic process
F0061462biological_processprotein localization to lysosome
F0065008biological_processregulation of biological quality
F0071230biological_processcellular response to amino acid stimulus
F0071233biological_processcellular response to L-leucine
F0071333biological_processcellular response to glucose stimulus
F0071456biological_processcellular response to hypoxia
F0071470biological_processcellular response to osmotic stress
F0071889molecular_function14-3-3 protein binding
F0140767molecular_functionenzyme-substrate adaptor activity
F1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
F1901331biological_processpositive regulation of odontoblast differentiation
F1902554cellular_componentserine/threonine protein kinase complex
F1904263biological_processpositive regulation of TORC1 signaling
F1905857biological_processpositive regulation of pentose-phosphate shunt
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005768cellular_componentendosome
G0005829cellular_componentcytosol
G0007175biological_processnegative regulation of epidermal growth factor-activated receptor activity
G0008270molecular_functionzinc ion binding
G0016020cellular_componentmembrane
G0031901cellular_componentearly endosome membrane
G0032266molecular_functionphosphatidylinositol-3-phosphate binding
G0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
G0046872molecular_functionmetal ion binding
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005768cellular_componentendosome
H0005829cellular_componentcytosol
H0007175biological_processnegative regulation of epidermal growth factor-activated receptor activity
H0008270molecular_functionzinc ion binding
H0016020cellular_componentmembrane
H0031901cellular_componentearly endosome membrane
H0032266molecular_functionphosphatidylinositol-3-phosphate binding
H0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
H0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
CMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues124
DetailsZN_FING: FYVE-type => ECO:0000255|PROSITE-ProRule:PRU00091
ChainResidueDetails
GASP817-PRO879
HASP817-PRO879
ESER836
ESER982
FSER44
FSER122
FSER836
FSER982

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00091
ChainResidueDetails
GCYS823
HCYS826
HCYS839
HCYS842
HCYS847
HCYS850
HCYS869
HCYS872
BGLY2238
BTRP2239
BVAL2240
GCYS826
BTHR2245
BMET2345
BILE2356
GCYS839
GCYS842
GCYS847
GCYS850
GCYS869
GCYS872
HCYS823

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER334
HSER334
AASP2357
BLYS2187
BASN2343
BASP2357
DLYS245
DLYS261

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GTHR516
HTHR516
CLYS313
DLYS305
DLYS313

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAP2K => ECO:0000269|PubMed:19460345
ChainResidueDetails
GSER586
HSER586

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAP2K => ECO:0000269|PubMed:19460345
ChainResidueDetails
GTHR870
HTHR870

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19460345
ChainResidueDetails
GLYS87
FSER738
HLYS87

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131
ChainResidueDetails
ESER791
FSER791

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260
ChainResidueDetails
ESER792
FSER792

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431
ChainResidueDetails
ESER855
FSER855

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER859
FSER859

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER863
FSER863

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ETHR865
FTHR865

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER877
FSER877

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
ELYS1097
FLYS1097

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
ETHR700
FTHR700
BLYS2066

site_idSWS_FT_FI17
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
ELYS932
ELYS948
FLYS932
FLYS948

237735

PDB entries from 2025-06-18

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