9F45
cryo-EM structure of human LST2 bound to human mTOR complex 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase mTOR | polymer | 2549 | 289258.0 | 2 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
| 2 | C, D (C, D) | Target of rapamycin complex subunit LST8 | polymer | 326 | 35910.1 | 2 | UniProt (Q9BVC4) Pfam (PF00400) | Homo sapiens (human) | TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
| 3 | E, F (E, F) | Regulatory-associated protein of mTOR | polymer | 1363 | 152764.7 | 2 | UniProt (Q8N122) Pfam (PF14538) Pfam (PF02985) Pfam (PF00400) | Homo sapiens (human) | Raptor,p150 target of rapamycin (TOR)-scaffold protein |
| 4 | G, H (G, H) | Lateral signaling target protein 2 homolog | polymer | 887 | 96604.5 | 2 | UniProt (Q9HCC9) Pfam (PF01363) | Homo sapiens (human) | hLst2,Zinc finger FYVE domain-containing protein 28 |
| 5 | I, J (A, B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) |
Sequence modifications
E, F: 1 - 1335 (UniProt: Q8N122)
| PDB | External Database | Details |
|---|---|---|
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| Glu -17 | - | expression tag |
| Gln -16 | - | expression tag |
| Lys -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Ile -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Glu -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 1149074.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1320.1 | |
| All* | Total formula weight | 1150394.5 |
