Summary for 9EYV
Entry DOI | 10.2210/pdb9eyv/pdb |
Descriptor | Protein arginine N-methyltransferase 5, N-terminally processed, Methylosome protein WDR77, (1~{S})-~{N}-[(4-fluorophenyl)methyl]-3-oxidanylidene-2-(1~{H}-pyrrolo[3,2-b]pyridin-2-ylmethyl)-1~{H}-isoindole-1-carboxamide, ... (6 entities in total) |
Functional Keywords | methyl transferase, inhibitor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 110331.74 |
Authors | |
Primary citation | Smith, J.M.,Barlaam, B.,Beattie, D.,Bradshaw, L.,Chan, H.M.,Chiarparin, E.,Collingwood, O.,Cooke, S.L.,Cronin, A.,Cumming, I.,Dean, E.,Debreczeni, J.E.,Del Barco Barrantes, I.,Diene, C.,Gianni, D.,Guerot, C.,Guo, X.,Guven, S.,Hayhow, T.G.,Hong, T.,Kemmitt, P.D.,Lamont, G.M.,Lamont, S.,Lynch, J.T.,McWilliams, L.,Moore, S.,Raubo, P.,Robb, G.R.,Robinson, J.,Scott, J.S.,Srinivasan, B.,Steward, O.,Stubbs, C.J.,Syson, K.,Tan, L.,Turner, O.,Underwood, E.,Urosevic, J.,Vazquez-Chantada, M.,Whittaker, A.L.,Wilson, D.M.,Winter-Holt, J.J. Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J.Med.Chem., 2024 Cited by PubMed: 39080842DOI: 10.1021/acs.jmedchem.4c00097 PDB entries with the same primary citation |
Experimental method |
Structure validation
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