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7ATL
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BU of 7atl by Molmil
EstCE1, a hydrolase with promiscuous acyltransferase activity
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Esterase, ...
Authors:Palm, G.J, Lammers, M, Berndt, L.
Deposit date:2020-10-30
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.478 Å)
Cite:Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases.
Angew.Chem.Int.Ed.Engl., 60, 2021
7PA5
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BU of 7pa5 by Molmil
Complex between the beta-lactamase CMY-2 with an inhibitory nanobody
Descriptor: Beta-lactamase, GLYCEROL, PHOSPHATE ION, ...
Authors:Frederic Cawez, F.C, Frederic Kerff, F.K, Moreno Galleni, M.G, Raphael Herman, R.H.
Deposit date:2021-07-29
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.184 Å)
Cite:Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C beta-Lactamases.
Antimicrob.Agents Chemother., 67, 2023
6I30
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BU of 6i30 by Molmil
Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C
Descriptor: (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Class C beta-lactamase PDC-301
Authors:Brem, J, Cahill, S.T, McDonough, M.A, Schofield, C.J.
Deposit date:2018-11-02
Release date:2019-02-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Studies on the inhibition of AmpC and other beta-lactamases by cyclic boronates.
Biochim Biophys Acta Gen Subj, 1863, 2019
7Y3Z
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BU of 7y3z by Molmil
Structure of a novel carboxylesterase FEH from Acinetobacter sp. DL-2
Descriptor: Fenoxaprop-p-ethyl hydrolase
Authors:Huang, Y, Liu, W.D, Zhang, Y.J, Duan, Y.J, Lu, M.L.
Deposit date:2022-06-13
Release date:2023-07-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a novel carboxylesterase FEH from Acinetobacter sp. DL-2
To Be Published
5TGF
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BU of 5tgf by Molmil
Crystal structure of putative beta-lactamase from Bacteroides dorei DSM 17855
Descriptor: CALCIUM ION, GLYCEROL, Uncharacterized protein
Authors:Nocek, B, Hatzos-Skintges, C, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2016-09-27
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal structure of a beta-lactamase from Bacteroides dorei DSM 17855
To Be Published
4XUX
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BU of 4xux by Molmil
Structure of ampC bound to RPX-7009 at 1.75 A
Descriptor: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Beta-lactamase, ...
Authors:Clifton, M.C, Abendroth, J.
Deposit date:2015-01-26
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J.Med.Chem., 58, 2015
3RJU
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BU of 3rju by Molmil
Crystal Structure of Beta-lactamase/D-alanine Carboxypeptidase from Yersinia pestis complexed with citrate
Descriptor: Beta-lactamase/D-alanine Carboxypeptidase, CITRIC ACID, GLYCEROL
Authors:Kim, Y, Zhou, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-04-15
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Beta-lactamase/D-alanine Carboxypeptidase from Yersinia pestis complexed with citrate
To be Published
3S22
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BU of 3s22 by Molmil
AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor
Descriptor: Beta-lactamase, CHLORIDE ION, [(2S,3R)-2-formyl-1-{[4-(methylamino)butyl]carbamoyl}pyrrolidin-3-yl]sulfamic acid
Authors:Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N.
Deposit date:2011-05-16
Release date:2011-06-29
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712
Bioorg.Med.Chem.Lett., 21, 2011
4LV0
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BU of 4lv0 by Molmil
AmpC beta-lactamase in complex with m-aminophenyl boronic acid
Descriptor: Beta-lactamase, M-AMINOPHENYLBORONIC ACID, PHOSPHATE ION
Authors:London, N, Eidam, O, Shoichet, B.K.
Deposit date:2013-07-25
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.652 Å)
Cite:Covalent docking of large libraries for the discovery of chemical probes.
Nat.Chem.Biol., 10, 2014
4LV2
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BU of 4lv2 by Molmil
AmpC beta-lactamase in complex with [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl] boronic acid
Descriptor: Beta-lactamase, PHOSPHATE ION, [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl]boronic acid
Authors:London, N, Eidam, O, Shoichet, B.K.
Deposit date:2013-07-25
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent docking of large libraries for the discovery of chemical probes.
Nat.Chem.Biol., 10, 2014
6FM7
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BU of 6fm7 by Molmil
Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes in complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, Beta-lactamase, ...
Authors:Pozzi, C, De Luca, F, Benvenuti, M, Di Pisa, F, Docquier, J.D, Mangani, S.
Deposit date:2018-01-30
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Atomic-Resolution Structure of a Class C beta-Lactamase and Its Complex with Avibactam.
ChemMedChem, 13, 2018
6G9T
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BU of 6g9t by Molmil
CRYSTAL STRUCTURE OF CMY-136 class C BETA-LACTAMASE
Descriptor: Beta-lactamase, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Zavala, A, Retailleau, P, Naas, T, Iorga, B.
Deposit date:2018-04-11
Release date:2019-02-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Genetic, Biochemical, and Structural Characterization of CMY-136 beta-Lactamase, a Peculiar CMY-2 Variant.
Acs Infect Dis., 5, 2019
6FM6
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BU of 6fm6 by Molmil
Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes
Descriptor: Beta-lactamase, SULFATE ION, TRIETHYLENE GLYCOL
Authors:Pozzi, C, De Luca, F, Di Pisa, F, Benvenuti, M, Docquier, J.D, Mangani, S.
Deposit date:2018-01-30
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Atomic-Resolution Structure of a Class C beta-Lactamase and Its Complex with Avibactam.
ChemMedChem, 13, 2018
4WBG
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BU of 4wbg by Molmil
Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam
Descriptor: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, ACETATE ION, Beta-lactamase, ...
Authors:Oguri, T, Shimizu-ibuka, A, Ishii, Y.
Deposit date:2014-09-03
Release date:2015-07-01
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Change Observed in the Active Site of Class C beta-Lactamase MOX-1 upon Binding to Aztreonam
Antimicrob.Agents Chemother., 59, 2015
4X68
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BU of 4x68 by Molmil
Crystal Structure of OP0595 complexed with AmpC
Descriptor: (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, NICKEL (II) ION
Authors:Yamada, M, Watanabe, T.
Deposit date:2014-12-07
Release date:2015-07-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:OP0595, a new diazabicyclooctane: mode of action as a serine beta-lactamase inhibitor, antibiotic and beta-lactam 'enhancer'
J.Antimicrob.Chemother., 70, 2015
4WZ4
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BU of 4wz4 by Molmil
Crystal structure of P. aeruginosa AmpC
Descriptor: Beta-lactamase, GLYCEROL, {(3R)-6-[(3-amino-1,2,4-thiadiazol-5-yl)oxy]-1-hydroxy-4,5-dimethyl-1,3-dihydro-2,1-benzoxaborol-3-yl}acetic acid
Authors:Ferguson, A.D.
Deposit date:2014-11-18
Release date:2015-08-05
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine beta-Lactamase Inhibitors.
ACS Infect Dis, 1, 2015
4WYY
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BU of 4wyy by Molmil
Crystal Structure of P. aeruginosa AmpC
Descriptor: Beta-lactamase, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Ferguson, A.D.
Deposit date:2014-11-18
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine beta-Lactamase Inhibitors.
ACS Infect Dis, 1, 2015
8JB7
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BU of 8jb7 by Molmil
Crystal structure of CMY-185
Descriptor: Beta-lactamase, SULFATE ION
Authors:Kawai, A, Doi, Y.
Deposit date:2023-05-08
Release date:2023-12-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185.
Mbio, 15, 2024
8JB8
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BU of 8jb8 by Molmil
Crystal structure of CMY-185 complex with ceftazidime
Descriptor: ACYLATED CEFTAZIDIME, Beta-lactamase
Authors:Kawai, A, Doi, Y.
Deposit date:2023-05-08
Release date:2023-12-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185.
Mbio, 15, 2024
2P9V
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BU of 2p9v by Molmil
Structure of AmpC beta-lactamase with cross-linked active site after exposure to small molecule inhibitor
Descriptor: Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Wyrembak, P.N, Pelto, R.B, Shoichet, B.K, Pratt, R.F.
Deposit date:2007-03-26
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:O-Aryloxycarbonyl Hydroxamates: New beta-Lactamase Inhibitors That Cross-Link the Active Site.
J.Am.Chem.Soc., 129, 2007
2PU4
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BU of 2pu4 by Molmil
AmpC beta-lacamase with bound covalent oxadiazole inhibitor
Descriptor: Beta-lactamase, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-05-08
Release date:2008-04-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2PU2
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BU of 2pu2 by Molmil
AmpC beta-lactamase with bound Phthalamide inhibitor
Descriptor: 2-[(1R)-1-CARBOXY-2-(4-HYDROXYPHENYL)ETHYL]-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-05-08
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2Q9M
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BU of 2q9m by Molmil
4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity
Descriptor: (1R,4S,7AS)-1-(1-FORMYLPROP-1-EN-1-YL)-4-METHOXY-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID, Beta-lactamase
Authors:Plantan, I, Selic, L, Mesar, T, Stefanic Anderluh, P, Oblak, M, Prezelj, A, Hesse, L, Andrejasic, M, Vilar, M, Turk, D, Kocijan, A, Prevec, T, Vilfan, G, Kocjan, D, Copar, A, Urleb, U, Solmajer, T.
Deposit date:2007-06-13
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity
J.Med.Chem., 50, 2007
2Q9N
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BU of 2q9n by Molmil
4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity
Descriptor: (1S,4R,7AR)-4-BUTOXY-1-[(1R)-1-FORMYLPROPYL]-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID, Beta-lactamase
Authors:Plantan, I, Selic, L, Mesar, T, Stefanic Anderluh, P, Oblak, M, Prezelj, A, Hesse, L, Andrejasic, M, Vilar, M, Turk, D, Kocijan, A, Prevec, T, Vilfan, G, Kocjan, D, Copar, A, Urleb, U, Solmajer, T.
Deposit date:2007-06-13
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity
J.Med.Chem., 50, 2007
3LY4
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BU of 3ly4 by Molmil
Crystal Structure of fluorophore-labeled Class A -lactamase PenP-E166Cb in complex with penicillin G
Descriptor: Beta-lactamase, OPEN FORM - PENICILLIN G
Authors:Zhao, Y.X, Leung, Y.C, Wong, W.T.
Deposit date:2010-02-26
Release date:2011-03-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of fluorophore-labeled Class A -lactamase PenP-E166Cb in complex with penicillin G
To be Published

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