2Q9N

4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity

Summary for 2Q9N

Entry DOI	10.2210/pdb2q9n/pdb
Related	1XX2
Descriptor	Beta-lactamase, (1S,4R,7AR)-4-BUTOXY-1-[(1R)-1-FORMYLPROPYL]-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	beta-lactamase inhibitor, tricyclic carbapenem, hydrolase
Biological source	Enterobacter cloacae
Cellular location	Periplasm (By similarity): P05364
Total number of polymer chains	1
Total formula weight	39349.92
Authors	Plantan, I.,Selic, L.,Mesar, T.,Stefanic Anderluh, P.,Oblak, M.,Prezelj, A.,Hesse, L.,Andrejasic, M.,Vilar, M.,Turk, D.,Kocijan, A.,Prevec, T.,Vilfan, G.,Kocjan, D.,Copar, A.,Urleb, U.,Solmajer, T. (deposition date: 2007-06-13, release date: 2007-08-21, Last modification date: 2023-08-30)
Primary citation	Plantan, I.,Selic, L.,Mesar, T.,Anderluh, P.S.,Oblak, M.,Prezelj, A.,Hesse, L.,Andrejasic, M.,Vilar, M.,Turk, D.,Kocijan, A.,Prevec, T.,Vilfan, G.,Kocjan, D.,Copar, A.,Urleb, U.,Solmajer, T. 4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity J.Med.Chem., 50:4113-4121, 2007 Cited by PubMed: 17665896 DOI: 10.1021/jm0703237 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation