4LV2

AmpC beta-lactamase in complex with [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl] boronic acid

Summary for 4LV2

• Entry DOI: 10.2210/pdb4lv2/pdb
• Related: 4LV0 4LV1 4LV3
• Descriptor: Beta-lactamase, [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl]boronic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ampc beta-lactamase, class c, hydrolase, boronic acid, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 80039.02

Authors

London, N.,Eidam, O.,Shoichet, B.K. (deposition date: 2013-07-25, release date: 2014-07-30, Last modification date: 2023-09-20)

• Primary citation: London, N.,Miller, R.M.,Krishnan, S.,Uchida, K.,Irwin, J.J.,Eidam, O.,Gibold, L.,Cimermancic, P.,Bonnet, R.,Shoichet, B.K.,Taunton, J.; Covalent docking of large libraries for the discovery of chemical probes.; Nat.Chem.Biol., 10:1066-1072, 2014; PubMed: 25344815; DOI: 10.1038/nchembio.1666

Experimental method

X-RAY DIFFRACTION (1.65 Å)