2Q9M
4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity
Summary for 2Q9M
Entry DOI | 10.2210/pdb2q9m/pdb |
Related | 1XX2 |
Descriptor | Beta-lactamase, (1R,4S,7AS)-1-(1-FORMYLPROP-1-EN-1-YL)-4-METHOXY-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | beta-lactamase inhibitor, tricyclic carbapenem, hydrolase |
Biological source | Enterobacter cloacae |
Cellular location | Periplasm (By similarity): P05364 |
Total number of polymer chains | 1 |
Total formula weight | 39305.83 |
Authors | Plantan, I.,Selic, L.,Mesar, T.,Stefanic Anderluh, P.,Oblak, M.,Prezelj, A.,Hesse, L.,Andrejasic, M.,Vilar, M.,Turk, D.,Kocijan, A.,Prevec, T.,Vilfan, G.,Kocjan, D.,Copar, A.,Urleb, U.,Solmajer, T. (deposition date: 2007-06-13, release date: 2007-08-21, Last modification date: 2023-08-30) |
Primary citation | Plantan, I.,Selic, L.,Mesar, T.,Anderluh, P.S.,Oblak, M.,Prezelj, A.,Hesse, L.,Andrejasic, M.,Vilar, M.,Turk, D.,Kocijan, A.,Prevec, T.,Vilfan, G.,Kocjan, D.,Copar, A.,Urleb, U.,Solmajer, T. 4-Substituted Trinems as Broad Spectrum beta-Lactamase Inhibitors: Structure-Based Design, Synthesis, and Biological Activity J.Med.Chem., 50:4113-4121, 2007 Cited by PubMed: 17665896DOI: 10.1021/jm0703237 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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