4WBG

Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam

Summary for 4WBG

• Entry DOI: 10.2210/pdb4wbg/pdb
• Related: 3W8K
• Descriptor: Beta-lactamase, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, aztreonam, acyl-intermediate, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 41662.39

Authors

Oguri, T.,Shimizu-ibuka, A.,Ishii, Y. (deposition date: 2014-09-03, release date: 2015-07-01, Last modification date: 2020-01-29)

• Primary citation: Oguri, T.,Ishii, Y.,Shimizu-Ibuka, A.; Conformational Change Observed in the Active Site of Class C beta-Lactamase MOX-1 upon Binding to Aztreonam; Antimicrob.Agents Chemother., 59:5069-5072, 2015; PubMed: 26055361; DOI: 10.1128/AAC.04428-14

Experimental method

X-RAY DIFFRACTION (1.9 Å)