3S22

AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor

Summary for 3S22

Entry DOI	10.2210/pdb3s22/pdb
Related	2WZX 2WZZ 3S1Y
Descriptor	Beta-lactamase, [(2S,3R)-2-formyl-1-{[4-(methylamino)butyl]carbamoyl}pyrrolidin-3-yl]sulfamic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Pseudomonas aeruginosa
Cellular location	Periplasm (By similarity): P24735
Total number of polymer chains	1
Total formula weight	40995.68
Authors	Scapin, G.,Lu, J.,Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2011-05-16, release date: 2011-06-29, Last modification date: 2013-06-26)
Primary citation	Chen, H.,Blizzard, T.A.,Kim, S.,Wu, J.,Young, K.,Park, Y.W.,Ogawa, A.M.,Raghoobar, S.,Painter, R.E.,Wisniewski, D.,Hairston, N.,Fitzgerald, P.,Sharma, N.,Scapin, G.,Lu, J.,Hermes, J.,Hammond, M.L. Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 Bioorg.Med.Chem.Lett., 21:4267-4270, 2011 Cited by PubMed: 21676616 DOI: 10.1016/j.bmcl.2011.05.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation