4XUX

Structure of ampC bound to RPX-7009 at 1.75 A

Summary for 4XUX

• Entry DOI: 10.2210/pdb4xux/pdb
• Related: 4XUZ
• Descriptor: Beta-lactamase, Vaborbactam, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Enterobacter cloacae
• Cellular location: Periplasm : P05364
• Total number of polymer chains: 1
• Total formula weight: 39955.31

Authors

Clifton, M.C.,Abendroth, J. (deposition date: 2015-01-26, release date: 2015-04-01, Last modification date: 2023-09-27)

• Primary citation: Hecker, S.J.,Reddy, K.R.,Totrov, M.,Hirst, G.C.,Lomovskaya, O.,Griffith, D.C.,King, P.,Tsivkovski, R.,Sun, D.,Sabet, M.,Tarazi, Z.,Clifton, M.C.,Atkins, K.,Raymond, A.,Potts, K.T.,Abendroth, J.,Boyer, S.H.,Loutit, J.S.,Morgan, E.E.,Durso, S.,Dudley, M.N.; Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.; J.Med.Chem., 58:3682-3692, 2015; PubMed: 25782055; DOI: 10.1021/acs.jmedchem.5b00127

Experimental method

X-RAY DIFFRACTION (1.75 Å)