2PU4

AmpC beta-lacamase with bound covalent oxadiazole inhibitor

Summary for 2PU4

• Entry DOI: 10.2210/pdb2pu4/pdb
• Related: 2PU2
• Descriptor: Beta-lactamase, DIMETHYL SULFOXIDE, TERT-BUTYL [(1R)-2-METHYL-1-(1,3,4-OXADIAZOL-2-YL)PROPYL]CARBAMATE, ... (6 entities in total)
• Functional Keywords: ampc beta-lactamase oxadiazole, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 80006.81

Authors

Babaoglu, K.,Shoichet, B.K. (deposition date: 2007-05-08, release date: 2008-04-15, Last modification date: 2017-10-18)

• Primary citation: Babaoglu, K.,Simeonov, A.,Irwin, J.J.,Nelson, M.E.,Feng, B.,Thomas, C.J.,Cancian, L.,Costi, M.P.,Maltby, D.A.,Jadhav, A.,Inglese, J.,Austin, C.P.,Shoichet, B.K.; Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.; J.Med.Chem., 51:2502-2511, 2008; PubMed: 18333608; DOI: 10.1021/jm701500e

Experimental method

X-RAY DIFFRACTION (2 Å)