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8XS3
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BU of 8xs3 by Molmil
Structure of MPXV B6 and D68 fab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D68_heavy chain, ...
Authors:wu, L.L, Sun, J.Q.
Deposit date:2024-01-08
Release date:2024-06-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections.
Nat Commun, 15, 2024
8W18
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BU of 8w18 by Molmil
The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms
Descriptor: Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain, Plasma protease C1 inhibitor
Authors:Garrigues, R.J, Garcia, B.L.
Deposit date:2024-02-15
Release date:2024-06-26
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation.
J Immunol., 213, 2024
8TYP
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BU of 8typ by Molmil
Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide
Descriptor: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Geisbrecht, B.V.
Deposit date:2023-08-25
Release date:2023-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.
J Immunol., 212, 2024
8TGT
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BU of 8tgt by Molmil
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein
Descriptor: 1,2-ETHANEDIOL, C4b-binding protein alpha chain, CALCIUM ION, ...
Authors:Kolesinski, P, Ghosh, P.
Deposit date:2023-07-13
Release date:2024-07-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M68 protein
To Be Published
8SM0
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BU of 8sm0 by Molmil
Crystal structure of human complement receptor 2 (CD21) in complex with Epstein-Barr virus major glycoprotein gp350
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement receptor type 2, Envelope glycoprotein gp350, ...
Authors:Chen, W.-H, Bu, W, Cohen, J.I, Kanekiyo, M, Joyce, M.G.
Deposit date:2023-04-25
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural Basis For Receptor Engagement And Virus Neutralization Through Epstein-Barr Virus Gp350
To Be Published
8SL1
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BU of 8sl1 by Molmil
Cryo-EM structure of PAPP-A2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Judge, R.A, Stoll, V.S, Eaton, D, Hao, Q, Bratkowski, M.A.
Deposit date:2023-04-20
Release date:2023-11-08
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition.
Commun Chem, 6, 2023
8QK3
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BU of 8qk3 by Molmil
Human Adenovirus type 11 fiber knob in complex with its cell receptors, Desmoglein-2 and CD46
Descriptor: Desmoglein-2, Fiber protein, Membrane cofactor protein
Authors:Effantin, G.
Deposit date:2023-09-14
Release date:2023-11-01
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis.
J.Virol., 97, 2023
8HGH
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BU of 8hgh by Molmil
Structure of 2:2 PAPP-A.STC2 complex
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION
Authors:Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
Deposit date:2022-11-14
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
8HGG
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BU of 8hgg by Molmil
Structure of 2:2 PAPP-A.ProMBP complex
Descriptor: Bone marrow proteoglycan, Pappalysin-1, ZINC ION
Authors:Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
Deposit date:2022-11-14
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
8GMN
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BU of 8gmn by Molmil
Crystal structure of human C1s in complex with inhibitor
Descriptor: Complement C1s subcomponent, SULFATE ION, [4-(1-aminophthalazin-6-yl)piperazin-1-yl](2-methylphenyl)methanone
Authors:Dougan, D.R, Lane, W.
Deposit date:2023-03-26
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.
J.Med.Chem., 66, 2023
8EOK
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BU of 8eok by Molmil
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-10-03
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8ENU
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BU of 8enu by Molmil
Structure of the C3bB proconvertase in complex with lufaxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-09-30
Release date:2023-08-09
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8D8O
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BU of 8d8o by Molmil
Cryo-EM structure of substrate unbound PAPP-A
Descriptor: Pappalysin-1, ZINC ION
Authors:Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D.
Deposit date:2022-06-08
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
8CJV
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BU of 8cjv by Molmil
Structure of bovine CD46 ectodomain (SCR 1-4)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Membrane cofactor protein
Authors:Aitkenhead, H, Stuart, D.I, El Omari, K.
Deposit date:2023-02-13
Release date:2023-07-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structure of Bovine CD46 Ectodomain.
Viruses, 15, 2023
8CI3
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BU of 8ci3 by Molmil
Structure of bovine CD46 ectodomain (SCR 1-2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Aitkenhead, H, David I Stuart, D.I, El Omari, K.
Deposit date:2023-02-08
Release date:2023-07-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of Bovine CD46 Ectodomain.
Viruses, 15, 2023
8B9F
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BU of 8b9f by Molmil
Structure of Echovirus 11 complexed with DAF (CD55) calculated from symmetry expansion
Descriptor: Complement decay-accelerating factor, Genome polyprotein, SPHINGOSINE
Authors:Stuart, D.I, Ren, J, Qin, L, Zhou, D.
Deposit date:2022-10-05
Release date:2022-12-07
Last modified:2023-01-04
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Switching of Receptor Binding Poses between Closely Related Enteroviruses.
Viruses, 14, 2022
8B8R
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BU of 8b8r by Molmil
Complex of Echovirus 11 with its attaching receptor decay-accelerating factor (CD55)
Descriptor: DECAY ACCELERATING FACTOR (CD55), SPHINGOSINE, VP1, ...
Authors:Stuart, D.I, Ren, J, Zhou, D, Qin, L.
Deposit date:2022-10-04
Release date:2022-12-07
Last modified:2023-01-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Switching of Receptor Binding Poses between Closely Related Enteroviruses.
Viruses, 14, 2022
8B0H
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BU of 8b0h by Molmil
2C9, C5b9-CD59 cryoEM structure
Descriptor: CD59 glycoprotein, Complement C5, Complement component C6, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0G
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BU of 8b0g by Molmil
2C9, C5b9-CD59 structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0F
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BU of 8b0f by Molmil
CryoEM structure of C5b8-CD59
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bubeck, D, Couves, E.C, Gardner, S.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8ACI
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BU of 8aci by Molmil
Structure of ARG-117 Fab in complex with a fragment of complement C2, neutral pH
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ARGX-117 Fab heavy chain, ARGX-117 Fab light chain, ...
Authors:Olesen, H.G, Andersen, G.R.
Deposit date:2022-07-05
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody
To be published
8ACF
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BU of 8acf by Molmil
Structure of the argX-117 in complex with a complement C2 fragment at low pH
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
Authors:Olesen, H.G, Andersen, G.R.
Deposit date:2022-07-05
Release date:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-function analysis of ARGX-117, a calcium- and pH-dependent clinical phase complement C2 blocking antibody
To be published
8A7E
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BU of 8a7e by Molmil
PAPP-A dimer in complex with its inhibitor STC2
Descriptor: CALCIUM ION, Pappalysin-1, Stanniocalcin-2, ...
Authors:Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C.
Deposit date:2022-06-20
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (5.02 Å)
Cite:Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
Nat Commun, 13, 2022
8A7D
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BU of 8a7d by Molmil
Partial dimer complex of PAPP-A and its inhibitor STC2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Pappalysin-1, ...
Authors:Kobbero, S.D, Gajhede, M, Mirza, O.A, Boesen, T, Oxvig, C.
Deposit date:2022-06-20
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
Nat Commun, 13, 2022
7ZMZ
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BU of 7zmz by Molmil
Engineered Interleukin 2 bound to CD25 receptor
Descriptor: Interleukin-2, Interleukin-2 receptor subunit alpha
Authors:Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S.
Deposit date:2022-04-20
Release date:2022-12-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Sci Immunol, 7, 2022

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PDB entries from 2024-09-18

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