8W18

The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms

This is a non-PDB format compatible entry.

Summary for 8W18

• Entry DOI: 10.2210/pdb8w18/pdb
• Descriptor: Plasma protease C1 inhibitor, Complement C1s subcomponent light chain, Complement C1s subcomponent heavy chain (3 entities in total)
• Functional Keywords: complement, c1s, c1 esterase inhibitor, michaelis complex, reactive center loop, exosite, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 88254.47

Authors

Garrigues, R.J.,Garcia, B.L. (deposition date: 2024-02-15, release date: 2024-06-26, Last modification date: 2024-07-24)

• Primary citation: Garrigues, R.J.,Garrison, M.P.,Garcia, B.L.; The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation.; J Immunol., 2024; PubMed: 38995166; DOI: 10.4049/jimmunol.2400194

Experimental method

X-RAY DIFFRACTION (3.94 Å)