8W18

The crystal structure of the Michaelis-Menten complex of a C1s/C1-INH at 3.94 Angstroms

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	I	Plasma protease C1 inhibitor	polymer	395	43997.4	1	UniProt (P05155) Pfam (PF00079) In PDB	Homo sapiens (human)	C1 Inh,C1Inh,C1 esterase inhibitor,C1-inhibiting factor,Serpin G1
2	B	Complement C1s subcomponent light chain	polymer	251	27668.5	1	UniProt (P09871) Pfam (PF00089) In PDB	Homo sapiens (human)
3	A	Complement C1s subcomponent heavy chain	polymer	151	16588.5	1	UniProt (P09871) Pfam (PF00084) In PDB	Homo sapiens (human)

Sequence modifications

I: 111 - 500 (UniProt: P05155)

PDB	External Database	Details
Gly 106	-	expression tag
Ser 107	-	expression tag
Thr 108	-	expression tag
Gly 109	-	expression tag
Ser 110	-	expression tag

B: 438 - 688 (UniProt: P09871)

PDB	External Database	Details
Ala 632	Ser 632	engineered mutation

A: 292 - 437 (UniProt: P09871)

PDB	External Database	Details
Gly 287	-	expression tag
Ser 288	-	expression tag
Thr 289	-	expression tag
Gly 290	-	expression tag
Ser 291	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	88254.5
All*	Total formula weight	88254.5

*Water molecules are not included.