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8V52
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Crystal structure of 2A10 Fab bound to Human TGF-beta3
Descriptor: 2A10 Fab Heavy Chain, 2A10 Fab Light chain, Transforming growth factor beta-3
Authors:Yin, J, Lupardus, P.J.
Deposit date:2023-11-30
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Isoform-selective TGF-beta 3 inhibition for systemic sclerosis.
Med, 5, 2024
1AGQ
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BU of 1agq by Molmil
GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
Descriptor: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
Authors:Eigenbrot, C, Gerber, N.
Deposit date:1997-03-25
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
6I9J
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BU of 6i9j by Molmil
Human transforming growth factor beta2 in a tetragonal crystal form
Descriptor: Transforming growth factor beta-2 proprotein
Authors:Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T.
Deposit date:2018-11-23
Release date:2019-07-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation.
Sci Rep, 9, 2019
6XM2
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BU of 6xm2 by Molmil
The structure of the 4A11.v7 antibody in complex with human TGFb2
Descriptor: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2
Authors:Lupardus, P.J, Yin, J.P.
Deposit date:2020-06-29
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med, 13, 2021
7ZJF
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BU of 7zjf by Molmil
R399E, a mutated form of GDF5, for disease modification of osteoarthritis
Descriptor: Growth/differentiation factor 5
Authors:Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K.
Deposit date:2022-04-10
Release date:2022-09-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol, 75, 2023
7L0J
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BU of 7l0j by Molmil
Structure of AMH bound to AMHR2-ECD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ...
Authors:Hart, K.N, Thompson, T.B.
Deposit date:2020-12-11
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family.
Proc.Natl.Acad.Sci.USA, 118, 2021
5MR9
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BU of 5mr9 by Molmil
Ligand-receptor complex.
Descriptor: Neurturin
Authors:Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and biophysical characterisation of the human complex - a role for heparan sulfate
To Be Published
6OMO
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BU of 6omo by Molmil
Human BMP6 homodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 6, ...
Authors:Juo, Z.S, Seeherman, H.
Deposit date:2019-04-19
Release date:2019-05-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
1WAQ
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BU of 1waq by Molmil
Crystal structure of human Growth and Differentiation Factor 5 (GDF-5)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2004-10-27
Release date:2005-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
J.Mol.Biol., 349, 2005
6OMN
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BU of 6omn by Molmil
Glycosylated BMP2 homodimer
Descriptor: Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Juo, Z.S, Seeherman, H.
Deposit date:2019-04-19
Release date:2019-05-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
8E3G
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BU of 8e3g by Molmil
BMP2/GDF5 heterodimer
Descriptor: Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5
Authors:Gipson, G.R, Nolan, K.T, Thompson, T.B.
Deposit date:2022-08-17
Release date:2023-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21, 2023
5JI1
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BU of 5ji1 by Molmil
Crystal Structure of GDF8
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Growth/differentiation factor 8
Authors:Walker, R.G, Thompson, T.B.
Deposit date:2016-04-21
Release date:2017-03-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15, 2017
1BMP
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BU of 1bmp by Molmil
BONE MORPHOGENETIC PROTEIN-7
Descriptor: BONE MORPHOGENETIC PROTEIN-7
Authors:Griffith, D.L, Scott, D.L.
Deposit date:1995-12-14
Release date:1997-07-23
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Proc.Natl.Acad.Sci.USA, 93, 1996
4KV5
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BU of 4kv5 by Molmil
scFv GC1009 in complex with TGF-beta1.
Descriptor: Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein
Authors:Wei, R, Moulin, A.G, Mathieu, M.
Deposit date:2013-05-22
Release date:2014-09-24
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
1ZKZ
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BU of 1zkz by Molmil
Crystal Structure of BMP9
Descriptor: Growth/differentiation factor 2
Authors:Brown, M.A, Zhao, Q, Baker, K.A, Naik, C, Chen, C, Pukac, L, Singh, M, Tsareva, T, Parice, Y, Mahoney, A, Roschke, V, Sanyal, I, Choe, S.
Deposit date:2005-05-04
Release date:2005-05-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structure of BMP-9 and functional interactions with pro-region and receptors
J.Biol.Chem., 280, 2005
4KXZ
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BU of 4kxz by Molmil
crystal structure of tgfb2 in complex with GC2008.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ...
Authors:Mathieu, M, Moulin, A.G, Wei, R.
Deposit date:2013-05-28
Release date:2014-09-24
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
4MID
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BU of 4mid by Molmil
Crystal Structure of Activin A/BMP2 chimera
Descriptor: AB204 Activin A/BMP2 chimera
Authors:Esquivies, L.
Deposit date:2013-08-30
Release date:2014-05-07
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.139 Å)
Cite:An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29, 2014
4MPL
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BU of 4mpl by Molmil
Crystal structure of BMP9 at 1.90 Angstrom
Descriptor: Growth/differentiation factor 2
Authors:Li, W, Morrell, N.W, Wei, Z.
Deposit date:2013-09-13
Release date:2014-09-17
Last modified:2021-06-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis.
J.Biol.Chem., 289, 2014
5E4G
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BU of 5e4g by Molmil
Crystal structure of human growth differentiation factor 11 (GDF-11)
Descriptor: Growth/differentiation factor 11, TETRAETHYLENE GLYCOL
Authors:Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A.
Deposit date:2015-10-06
Release date:2016-03-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human GDF11.
Acta Crystallogr.,Sect.F, 72, 2016
5F3H
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BU of 5f3h by Molmil
Structure of myostatin in complex with humanized RK35 antibody
Descriptor: Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain
Authors:Parris, K.D, Mosyak, L.
Deposit date:2015-12-02
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
5F3B
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BU of 5f3b by Molmil
Structure of myostatin in complex with chimeric RK35 antibody
Descriptor: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
Authors:Parris, K.D, Mosyak, L.
Deposit date:2015-12-02
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
4N1D
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BU of 4n1d by Molmil
Nodal/BMP2 chimera NB250
Descriptor: Nodal/BMP2 chimera protein
Authors:Esquivies, L.
Deposit date:2013-10-04
Release date:2013-12-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
3BMP
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BU of 3bmp by Molmil
HUMAN BONE MORPHOGENETIC PROTEIN-2 (BMP-2)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN (BONE MORPHOGENETIC PROTEIN 2 (BMP-2))
Authors:Scheufler, C, Sebald, W, Huelsmeyer, M.
Deposit date:1999-03-12
Release date:2000-03-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution.
J.Mol.Biol., 287, 1999
3BK3
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BU of 3bk3 by Molmil
Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2
Descriptor: Bone morphogenetic protein 2, Crossveinless 2
Authors:Mueller, T.D, Sebald, W, Zhang, J.-L.
Deposit date:2007-12-05
Release date:2008-05-27
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
Dev.Cell, 14, 2008
8BWN
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BU of 8bwn by Molmil
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV)
Descriptor: CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1
Authors:Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C.
Deposit date:2022-12-07
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024

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