5D1C
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CRYSTAL STRUCTURE OF D233G-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.422 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5D1D
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CRYSTAL STRUCTURE OF P91L-Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
5FCW
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HDAC8 COMPLEXED WITH A HYDROXAMIC ACID
Descriptor:Histone deacetylase 8, 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide, ZINC ION, ...
Authors:Cole, K.E., Perry, K.
Deposit date:2015-12-15
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
J.Struct.Biol., 195, 2016
2V5X
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CRYSTAL STRUCTURE OF HDAC8-INHIBITOR COMPLEX
Descriptor:HISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ...
Authors:Di Marco, S., Vannini, A., Volpari, C., Gallinari, P., Jones, P., Mattu, M., Carfi, A., Defrancesco, R., Steinkuhler, C.
Deposit date:2007-07-10
Release date:2007-09-04
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
1VKG
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH CRA-19156
Descriptor:Histone deacetylase 8, ZINC ION, SODIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-13
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T67
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH MS-344
Descriptor:Histone deacetylase 8, ZINC ION, SODIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
6HSK
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CRYSTAL STRUCTURE OF A HUMAN HDAC8 L6 LOOP MUTANT COMPLEXED WITH QUISINOSTAT
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Marek, M., Shaik, T.B., Ramos-Morales, E., Romier, C.
Deposit date:2018-10-01
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
2V5W
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CRYSTAL STRUCTURE OF HDAC8-SUBSTRATE COMPLEX
Descriptor:HISTONE DEACETYLASE 8, GLYCYL-GLYCYL-GLYCINE, PEPTIDIC SUBSTRATE, ...
Authors:Di Marco, S., Vannini, A., Volpari, C.
Deposit date:2007-07-10
Release date:2007-09-04
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex
Embo Rep., 8, 2007
4RN0
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8, (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione, ZINC ION, ...
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
4RN1
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
4RN2
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CRYSTAL STRUCTURE OF S39D HDAC8 IN COMPLEX WITH A LARGAZOLE ANALOGUE.
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, D.W.
Deposit date:2014-10-22
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8.
Biochemistry, 54, 2015
6ODA
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CRYSTAL STRUCTURE OF HDAC8 IN COMPLEX WITH COMPOUND 2
Descriptor:Histone deacetylase 8, N-{2-[3-(hydroxyamino)-3-oxopropyl]phenyl}-3-(trifluoromethyl)benzamide, ZINC ION, ...
Authors:Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
Deposit date:2019-03-26
Release date:2020-04-01
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors
To Be Published
6ODB
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CRYSTAL STRUCTURE OF HDAC8 IN COMPLEX WITH COMPOUND 3
Descriptor:Histone deacetylase 8, N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide, ZINC ION, ...
Authors:Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
Deposit date:2019-03-26
Release date:2020-04-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors
To Be Published
6ODC
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CRYSTAL STRUCTURE OF HDAC8 IN COMPLEX WITH COMPOUND 30
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
Deposit date:2019-03-26
Release date:2020-04-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitors
To Be Published
1T64
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH TRICHOSTATIN A
Descriptor:Histone deacetylase 8, ZINC ION, CALCIUM ION, ...
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
1T69
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CRYSTAL STRUCTURE OF HUMAN HDAC8 COMPLEXED WITH SAHA
Descriptor:Histone deacetylase 8, ZINC ION, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
Authors:Somoza, J.R., Skene, R.J., Katz, B.A., Mol, C., Ho, J.D., Jennings, A.J., Luong, C., Arvai, A., Buggy, J.J., Chi, E., Tang, J., Sang, B.-C., Verner, E., Wynands, R., Leahy, E.M., Dougan, D.R., Snell, G., Navre, M., Knuth, M.W., Swanson, R.V., McRee, D.E., Tari, L.W.
Deposit date:2004-05-05
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12, 2004
4QA0
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CRYSTAL STRUCTURE OF C153F HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.242 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA1
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CRYSTAL STRUCTURE OF A188T HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8, POTASSIUM ION, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA2
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CRYSTAL STRUCTURE OF I243N HDAC8 IN COMPLEX WITH SAHA
Descriptor:Histone deacetylase 8, POTASSIUM ION, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.377 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA3
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CRYSTAL STRUCTURE OF T311M HDAC8 IN COMPLEX WITH TRICHOSTATIN A (TSA)
Descriptor:Histone deacetylase 8, TRICHOSTATIN A, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.876 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA4
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CRYSTAL STRUCTURE OF H334R HDAC8 IN COMPLEX WITH M344
Descriptor:Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA5
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CRYSTAL STRUCTURE OF A188T/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA6
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CRYSTAL STRUCTURE OF I243N/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
4QA7
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CRYSTAL STRUCTURE OF H334R/Y306F HDAC8 IN COMPLEX WITH A TETRAPEPTIDE SUBSTRATE
Descriptor:Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ...
Authors:Decroos, C., Bowman, C.B., Moser, J.-A.S., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2014-05-02
Release date:2014-08-06
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9, 2014
5D1B
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CRYSTAL STRUCTURE OF G117E HDAC8 IN COMPLEX WITH TSA
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Decroos, C., Christianson, N.H., Gullett, L.E., Bowman, C.M., Christianson, K.E., Deardorff, M.A., Christianson, D.W.
Deposit date:2015-08-04
Release date:2015-10-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
Biochemistry, 54, 2015
167327
PDB entries from 2020-08-05