2V5X
Crystal structure of HDAC8-inhibitor complex
Summary for 2V5X
Entry DOI | 10.2210/pdb2v5x/pdb |
Related | 1T64 1T67 1T69 1VKG 1W22 2V5W |
Descriptor | HISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | hydroxamate inhibitor, chromatin regulator, histone deacetylase, p53, hdac, hdac8, nucleus, hydrolase, repressor, chromatin, drug design, deacetylation, transcription, transcription regulation, nuclear protein, peptidic substrate |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 87940.59 |
Authors | Di Marco, S.,Vannini, A.,Volpari, C.,Gallinari, P.,Jones, P.,Mattu, M.,Carfi, A.,Defrancesco, R.,Steinkuhler, C. (deposition date: 2007-07-10, release date: 2007-09-04, Last modification date: 2023-12-13) |
Primary citation | Vannini, A.,Volpari, C.,Gallinari, P.,Jones, P.,Mattu, M.,Carfi, A.,Defrancesco, R.,Steinkuhler, C.,Di Marco, S. Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8:879-, 2007 Cited by PubMed: 17721440DOI: 10.1038/SJ.EMBOR.7401047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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