2V5X
Crystal structure of HDAC8-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | HISTONE DEACETYLASE 8 | polymer | 388 | 43202.9 | 2 | UniProt (Q9BY41) Pfam (PF00850) In PDB | HOMO SAPIENS (HUMAN) | HDAC8, HD8 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | A, B | (2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE | non-polymer | 623.7 | 2 | Chemie (V5X) | |||
| 5 | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
A, B: 378 - 388 (PDB: 2V5X)
| PDB | External Database | Details |
|---|---|---|
| Asp 39 | Ser 39 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86405.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1534.7 | |
| All* | Total formula weight | 87940.6 |
