Crystal Structure of human HDAC8 complexed with SAHA

Summary for 1T69

Related1T64 1T67
DescriptorHistone deacetylase 8, ZINC ION, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE (3 entities in total)
Functional Keywordshistone deacetylase, zinc hydrolase, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9BY41
Total number of polymer chains1
Total molecular weight42132.21
Primary citation
Somoza, J.R.,Skene, R.J.,Katz, B.A.,Mol, C.,Ho, J.D.,Jennings, A.J.,Luong, C.,Arvai, A.,Buggy, J.J.,Chi, E.,Tang, J.,Sang, B.-C.,Verner, E.,Wynands, R.,Leahy, E.M.,Dougan, D.R.,Snell, G.,Navre, M.,Knuth, M.W.,Swanson, R.V.,McRee, D.E.,Tari, L.W.
Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Structure, 12:1325-1334, 2004
PubMed: 15242608 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2004.04.012
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers9 1.4% 16.9% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02