4RN0
Crystal structure of S39D HDAC8 in complex with a largazole analogue.
Summary for 4RN0
Entry DOI | 10.2210/pdb4rn0/pdb |
Related | 4RN1 4RN2 |
Descriptor | Histone deacetylase 8, (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione, ZINC ION, ... (7 entities in total) |
Functional Keywords | metalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, largazole analogue, thiol inhibitor, arginase/deacetylase fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9BY41 |
Total number of polymer chains | 2 |
Total formula weight | 87959.75 |
Authors | Decroos, C.,Christianson, D.W. (deposition date: 2014-10-22, release date: 2015-04-08, Last modification date: 2023-09-20) |
Primary citation | Decroos, C.,Clausen, D.J.,Haines, B.E.,Wiest, O.,Williams, R.M.,Christianson, D.W. Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54:2126-2135, 2015 Cited by PubMed: 25793284DOI: 10.1021/acs.biochem.5b00010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.761 Å) |
Structure validation
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