4RN2

Crystal structure of S39D HDAC8 in complex with a largazole analogue.

Summary for 4RN2

Entry DOI	10.2210/pdb4rn2/pdb
Related	4RN0 4RN1
Descriptor	Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	metalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, largazole analogue, thiol inhibitor, arginase/deacetylase fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9BY41
Total number of polymer chains	2
Total formula weight	87786.52
Authors	Decroos, C.,Christianson, D.W. (deposition date: 2014-10-22, release date: 2015-04-08, Last modification date: 2023-09-20)
Primary citation	Decroos, C.,Clausen, D.J.,Haines, B.E.,Wiest, O.,Williams, R.M.,Christianson, D.W. Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8. Biochemistry, 54:2126-2135, 2015 Cited by PubMed: 25793284 DOI: 10.1021/acs.biochem.5b00010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation