5FCW

HDAC8 Complexed with a Hydroxamic Acid

Summary for 5FCW

• Entry DOI: 10.2210/pdb5fcw/pdb
• Descriptor: Histone deacetylase 8, 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide, ZINC ION, ... (7 entities in total)
• Functional Keywords: histone deacetylase, hdac8, hydroxamic acid, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9BY41
• Total number of polymer chains: 2
• Total formula weight: 86899.30

Authors

Cole, K.E.,Perry, K. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2024-03-06)

• Primary citation: Tabackman, A.A.,Frankson, R.,Marsan, E.S.,Perry, K.,Cole, K.E.; Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.; J.Struct.Biol., 195:373-378, 2016; PubMed: 27374062; DOI: 10.1016/j.jsb.2016.06.023

Experimental method

X-RAY DIFFRACTION (1.979 Å)