5FCW
HDAC8 Complexed with a Hydroxamic Acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 8 | polymer | 383 | 42631.3 | 2 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (Human) | HD8 |
| 2 | C, G, J, K (A, B) | 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide | non-polymer | 263.3 | 4 | Chemie (5YA) | |||
| 3 | D, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, I (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F (A) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 6 | L (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| His 378 | - | expression tag |
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85262.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1636.6 | |
| All* | Total formula weight | 86899.3 |
