5FCW

HDAC8 Complexed with a Hydroxamic Acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Histone deacetylase 8	polymer	383	42631.3	2	UniProt (Q9BY41) Pfam (PF00850) In PDB	Homo sapiens (Human)	HD8
2	A, B	4-naphthalen-1-yl-~{N}-oxidanyl-benzamide	non-polymer		263.3	4	Chemie (5YA)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
5	A	HEXAETHYLENE GLYCOL	non-polymer		282.3	1	Chemie (P6G)
6	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7		water	water		18.0	414	Chemie (HOH)

Sequence modifications

A, B: 1 - 377 (UniProt: Q9BY41)

PDB	External Database	Details
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85262.7
Non-Polymers*	Number of molecules	10
	Total formula weight	1636.6
All*	Total formula weight	86899.3

*Water molecules are not included.