5D1D

Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate

Summary for 5D1D

• Entry DOI: 10.2210/pdb5d1d/pdb
• Related: 5D1B 5D1C
• Descriptor: Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, ZINC ION, ... (5 entities in total)
• Functional Keywords: hydrolase, histone deacetylase, arginase/deacetylase fold, enzyme substrate complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 88425.24

Authors

Decroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2015-08-04, release date: 2015-10-21, Last modification date: 2023-11-15)

• Primary citation: Decroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W.; Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.; Biochemistry, 54:6501-6513, 2015; PubMed: 26463496; DOI: 10.1021/acs.biochem.5b00881

Experimental method

X-RAY DIFFRACTION (2.011 Å)