4QA4

Crystal structure of H334R HDAC8 in complex with M344

Summary for 4QA4

Entry DOI	10.2210/pdb4qa4/pdb
Related	4QA0 4QA1 4QA2 4QA3 4QA5 4QA6 4QA7
Descriptor	Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ... (6 entities in total)
Functional Keywords	metalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, cornelia de lange syndrome, arginase/deacetylase fold
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9BY41
Total number of polymer chains	1
Total formula weight	43978.32
Authors	Decroos, C.,Bowman, C.B.,Moser, J.-A.S.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2014-05-02, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citation	Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9:2157-2164, 2014 Cited by PubMed: 25075551 DOI: 10.1021/cb5003762 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation