4QA4
Crystal structure of H334R HDAC8 in complex with M344
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone deacetylase 8 | polymer | 389 | 43251.0 | 1 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (human) | HD8 |
| 2 | B (A) | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | non-polymer | 307.4 | 1 | Chemie (B3N) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F, G, H (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | I (A) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Arg 334 | His 334 | engineered mutation |
| Ile 378 | - | expression tag |
| Glu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Arg 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Ser 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43251.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 727.3 | |
| All* | Total formula weight | 43978.3 |
