Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate

Summary for 4QA7

Related4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6
DescriptorHistone deacetylase 8, tetrapeptide substrate, ZINC ION, ... (7 entities in total)
Functional Keywordsmetalloenzyme, hydrolase, histone deacetylase, enzyme substrate complex, cornelia de lange syndrome, arginase/deacetylase fold
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9BY41
Total number of polymer chains2
Total molecular weight44325.74
Decroos, C.,Bowman, C.B.,Moser, J.-A.S.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2014-05-02, release date: 2014-08-06, Last modification date: 2014-10-01)
Primary citation
Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W.
Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
Acs Chem.Biol., 9:2157-2164, 2014
PubMed: 25075551 (PDB entries with the same primary citation)
DOI: 10.1021/cb5003762
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24020.3%2.0%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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