4QA7
Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone deacetylase 8 | polymer | 389 | 43235.0 | 1 | UniProt (Q9BY41) Pfam (PF00850) In PDB | Homo sapiens (human) | HD8 |
2 | B | tetrapeptide substrate | polymer | 5 | 679.8 | 1 | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | B | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 1 | Chemie (MCM) | |||
6 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | water | water | 18.0 | 49 | Chemie (HOH) |
Sequence modifications
A: 1 - 377 (UniProt: Q9BY41)
PDB | External Database | Details |
---|---|---|
Phe 306 | Tyr 306 | engineered mutation |
Arg 334 | His 334 | engineered mutation |
Ile 378 | - | expression tag |
Glu 379 | - | expression tag |
Gly 380 | - | expression tag |
Arg 381 | - | expression tag |
Gly 382 | - | expression tag |
Ser 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
His 387 | - | expression tag |
His 388 | - | expression tag |
His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43914.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 410.9 | |
All* | Total formula weight | 44325.7 |