4QA5
Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate
Summary for 4QA5
Entry DOI | 10.2210/pdb4qa5/pdb |
Related | 4QA0 4QA1 4QA2 4QA3 4QA4 4QA6 4QA7 |
Descriptor | Histone deacetylase 8, tetrapeptide substrate, ZINC ION, ... (8 entities in total) |
Functional Keywords | metalloenzyme, hydrolase, histone deacetylase, enzyme substrate complex, cornelia de lange syndrome, arginase/deacetylase fold |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q9BY41 |
Total number of polymer chains | 4 |
Total formula weight | 88605.63 |
Authors | Decroos, C.,Bowman, C.B.,Moser, J.-A.S.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2014-05-02, release date: 2014-08-06, Last modification date: 2023-12-06) |
Primary citation | Decroos, C.,Bowman, C.M.,Moser, J.A.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9:2157-2164, 2014 Cited by PubMed: 25075551DOI: 10.1021/cb5003762 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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