4QA5
Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 8 | polymer | 389 | 43246.0 | 2 | UniProt (Q9BY41) Pfam (PF00850) | Homo sapiens (human) | HD8 |
| 2 | C, D (C, D) | tetrapeptide substrate | polymer | 5 | 679.8 | 2 | |||
| 3 | E, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, K, L (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | I (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | M, N (C, D) | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 2 | Chemie (MCM) | |||
| 8 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 626 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 377 (UniProt: Q9BY41)
| PDB | External Database | Details |
|---|---|---|
| Thr 188 | Ala 188 | engineered mutation |
| Phe 306 | Tyr 306 | engineered mutation |
| Ile 378 | - | expression tag |
| Glu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Arg 381 | - | expression tag |
| Gly 382 | - | expression tag |
| Ser 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
| His 387 | - | expression tag |
| His 388 | - | expression tag |
| His 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 87851.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 754.0 | |
| All* | Total formula weight | 88605.6 |
