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1GFY
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BU of 1gfy by Molmil
RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F.
Deposit date:2000-06-26
Release date:2000-07-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
2NLK
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BU of 2nlk by Molmil
Crystal structure of D1 and D2 catalytic domains of human Protein Tyrosine Phosphatase Gamma (D1+D2 PTPRG)
Descriptor: Protein tyrosine phosphatase, receptor type, G variant (Fragment)
Authors:Filippakopoulos, P, Gileadi, O, Johansson, C, Ugochukwu, E, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2006-10-20
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
4GS0
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BU of 4gs0 by Molmil
Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide
Descriptor: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6
Authors:Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J.
Deposit date:2012-08-27
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7961 Å)
Cite:Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
J.Struct.Biol., 181, 2013
2QBR
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BU of 2qbr by Molmil
Crystal structure of ptp1b-inhibitor complex
Descriptor: 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W.
Deposit date:2007-06-18
Release date:2008-03-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
J.Med.Chem., 50, 2007
6J6U
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BU of 6j6u by Molmil
Rat PTPRZ D1-D2 domain
Descriptor: Receptor-type tyrosine-protein phosphatase zeta
Authors:Sugawara, H.
Deposit date:2019-01-15
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:A head-to-toe dimerization has physiological relevance for ligand-induced inactivation of protein tyrosine receptor type Z.
J.Biol.Chem., 294, 2019
6KRX
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BU of 6krx by Molmil
Crystal Structure of AtPTP1 at 1.7 angstrom
Descriptor: CITRATE ANION, IODIDE ION, Protein-tyrosine-phosphatase PTP1
Authors:Zhao, Y.Y, Luo, Z.P, Wang, J, Wu, J.W.
Deposit date:2019-08-22
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:AtPTP1 positively mediates brassinosteroid signaling from receptor kinases to GSK3-like kinase BIN2
To Be Published
6KRW
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BU of 6krw by Molmil
Crystal Structure of AtPTP1 at 1.4 angstrom
Descriptor: CITRATE ANION, DI(HYDROXYETHYL)ETHER, IODIDE ION, ...
Authors:Zhao, Y.Y, Luo, Z.P, Wang, J, Wu, J.W.
Deposit date:2019-08-22
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of AtPTP1 at 1.4 Angstroms
To Be Published
6KZQ
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BU of 6kzq by Molmil
structure of PTP-MEG2 and NSF-pY83 peptide complex
Descriptor: NSF-pY83 peptide, Tyrosine-protein phosphatase non-receptor type 9
Authors:Xu, Y.F, Chen, X, Yu, X, Sun, J.P.
Deposit date:2019-09-25
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Embo Rep., 22, 2021
6L03
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BU of 6l03 by Molmil
structure of PTP-MEG2 and MUNC18-1-pY145 peptide complex
Descriptor: Tyrosine-protein phosphatase non-receptor type 9, stxbp1-pY145 peptide
Authors:Xu, Y.F, Chen, X, Yu, X, Sun, J.P.
Deposit date:2019-09-25
Release date:2020-09-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.084 Å)
Cite:PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Embo Rep., 22, 2021
4QBW
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BU of 4qbw by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P.
Deposit date:2014-05-08
Release date:2015-02-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57, 2014
4QBE
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BU of 4qbe by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X.
Deposit date:2014-05-08
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C, 2014
4PVG
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BU of 4pvg by Molmil
Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79
Descriptor: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11
Authors:Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z.
Deposit date:2014-03-17
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79
To be Published
4QAP
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BU of 4qap by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P.
Deposit date:2014-05-05
Release date:2015-02-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57, 2014
1WCH
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BU of 1wch by Molmil
Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Descriptor: PHOSPHATE ION, PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13
Authors:Villa, F, Deak, M, Bloomberg, G.B, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-11-16
Release date:2004-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Ptpl1/Fap-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer: Eveidence for a Second Phosphotyrosine Substrate Recognition Pocket
J.Biol.Chem., 280, 2005
4QAH
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BU of 4qah by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X.
Deposit date:2014-05-05
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C, 2014
8EXI
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BU of 8exi by Molmil
Crystal structure of apo PTP1B D181A/Q262A phosphatase domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXJ
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BU of 8exj by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK1 activation loop peptide, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXM
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BU of 8exm by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain with a JAK3 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK3 activation loop peptide, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EXN
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BU of 8exn by Molmil
Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Non-receptor tyrosine-protein kinase TYK2 activation loop peptide, PHOSPHATE ION, ...
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-25
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
8EYC
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BU of 8eyc by Molmil
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide
Descriptor: Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2022-10-26
Release date:2023-08-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure guided studies of the interaction between PTP1B and JAK.
Commun Biol, 6, 2023
1XXP
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BU of 1xxp by Molmil
Yersinia YopH (residues 163-468) C403S binds phosphotyrosyl peptide at two sites
Descriptor: Hexapeptide ASP-ALA-ASP-GLU-PTR-CLE, Protein-tyrosine phosphatase yopH
Authors:Ivanov, M.I, Stuckey, J.A, Schubert, H.L, Saper, M.A, Bliska, J.B.
Deposit date:2004-11-07
Release date:2005-03-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two substrate-targeting sites in the Yersinia protein tyrosine phosphatase co-operate to promote bacterial virulence
Mol.Microbiol., 55, 2005
4QUN
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BU of 4qun by Molmil
Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant
Descriptor: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3
Authors:Chen, K.E, Meng, T.C, Wang, A.H.J.
Deposit date:2014-07-11
Release date:2014-12-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation.
Sci.Signal., 7, 2014
4QUM
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BU of 4qum by Molmil
Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide
Descriptor: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3
Authors:Chen, K.E, Meng, T.C, Wang, A.H.J.
Deposit date:2014-07-10
Release date:2014-12-10
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation.
Sci.Signal., 7, 2014
4RDD
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BU of 4rdd by Molmil
Co-crystal structure of SHP2 in complex with a Cefsulodin derivative
Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11
Authors:Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y.
Deposit date:2014-09-18
Release date:2015-07-01
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015
4RH5
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BU of 4rh5 by Molmil
Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide
Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3
Authors:Chen, K.-E, Meng, T.C, Wang, A.H.-J.
Deposit date:2014-10-01
Release date:2015-03-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Structure, 23, 2015

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