2QBR

Crystal structure of ptp1b-inhibitor complex

Summary for 2QBR

Entry DOI	10.2210/pdb2qbr/pdb
Related	2QBP 2QBQ 2QBS
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35296.04
Authors	Xu, W. (deposition date: 2007-06-18, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citation	Wilson, D.P.,Wan, Z.K.,Xu, W.X.,Kirincich, S.J.,Follows, B.C.,Joseph-McCarthy, D.,Foreman, K.,Moretto, A.,Wu, J.,Zhu, M.,Binnun, E.,Zhang, Y.L.,Tam, M.,Erbe, D.V.,Tobin, J.,Xu, X.,Leung, L.,Shilling, A.,Tam, S.Y.,Mansour, T.S.,Lee, J. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50:4681-4698, 2007 Cited by PubMed: 17705360 DOI: 10.1021/jm0702478 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation