4RH5

Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide

Summary for 4RH5

Entry DOI	10.2210/pdb4rh5/pdb
Related	2B49 4QUM 4RH9 4RHG 4RI4 4RI5
Descriptor	Tyrosine-protein phosphatase non-receptor type 3, Epidermal growth factor receptor substrate 15 (3 entities in total)
Functional Keywords	alpha beta, hydrolase, hydrolase-protein binding complex, hydrolase/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side: P26045 Cytoplasm. Isoform 2: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : P42566
Total number of polymer chains	2
Total formula weight	36011.67
Authors	Chen, K.-E.,Meng, T.C.,Wang, A.H.-J. (deposition date: 2014-10-01, release date: 2015-03-11, Last modification date: 2023-12-06)
Primary citation	Chen, K.E.,Li, M.Y.,Chou, C.C.,Ho, M.R.,Chen, G.C.,Meng, T.C.,Wang, A.H. Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23:653-664, 2015 Cited by PubMed: 25728925 DOI: 10.1016/j.str.2015.01.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation